2-{[3-(5-amino-1H-1,2,4-triazol-3-yl)propyl](4-fluorophenyl)amino}ethan-1-ol

Base Information

• Chemical Name: 2-{[3-(5-amino-1H-1,2,4-triazol-3-yl)propyl](4-fluorophenyl)amino}ethan-1-ol
• CAS No.: 1609980-51-9
• Molecular Formula: C₁₃H₁₈FN₅O
• Molecular Weight: 279.317
• Mol file: 1609980-51-9.mol

Synonyms:2-{[3-(5-amino-1H-1,2,4-triazol-3-yl)propyl](4-fluorophenyl)amino}ethan-1-ol

Chemical Property of 2-{[3-(5-amino-1H-1,2,4-triazol-3-yl)propyl](4-fluorophenyl)amino}ethan-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-{[3-(5-amino-1H-1,2,4-triazol-3-yl)propyl](4-fluorophenyl)amino}ethan-1-ol

There total 3 articles about 2-{[3-(5-amino-1H-1,2,4-triazol-3-yl)propyl](4-fluorophenyl)amino}ethan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

methyl 4-[(4-fluorophenyl)(2-hydroxyethyl)amino]butanoate (1609980-50-8) + aminoguanidine bicarbonate (2582-30-1) → 2-{[3-(5-amino-1H-1,2,4-triazol-3-yl)propyl](4-fluorophenyl)amino}ethan-1-ol (1609980-51-9)

Guidance literature:

With pyridine; acetic acid; at 125 ℃; for 37h;

Reference yield:

4-fluoroaniline (371-40-4) → 2-{[3-(5-amino-1H-1,2,4-triazol-3-yl)propyl](4-fluorophenyl)amino}ethan-1-ol (1609980-51-9)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 80 °C

2: potassium carbonate / N,N-dimethyl-formamide / 80 °C

3: pyridine; acetic acid / 37 h / 125 °C

With pyridine; potassium carbonate; acetic acid; In N,N-dimethyl-formamide;

Reference yield:

2-[(4-fluorophenyl)amino]ethan-1-ol (702-17-0) → 2-{[3-(5-amino-1H-1,2,4-triazol-3-yl)propyl](4-fluorophenyl)amino}ethan-1-ol (1609980-51-9)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 80 °C

2: pyridine; acetic acid / 37 h / 125 °C

With pyridine; potassium carbonate; acetic acid; In N,N-dimethyl-formamide;

upstream raw materials:

4-fluoroaniline

2-[(4-fluorophenyl)amino]ethan-1-ol

methyl 4-[(4-fluorophenyl)(2-hydroxyethyl)amino]butanoate

aminoguanidine bicarbonate

Downstream raw materials:

2-[(3-{5,7-diethyl[1,2,4]triazolo[1,5-a]pyrimidin-2-yl}propyl)(4-fluorophenyl)amino]ethan-1-ol

2-[(3-{5,7-diethyl[1,2,4]triazolo[1,5-a]pyrimidin-2-yl}propyl)(4-fluorophenyl)amino]ethyl acetate