Aminoguanidine bicarbonate

Base Information

• Chemical Name: Aminoguanidine bicarbonate
• CAS No.: 2582-30-1
• Molecular Formula: C2H8N4O3
• Molecular Weight: 136.111
• Hs Code.: 2925.20
• European Community (EC) Number: 219-956-7,606-889-7
• NSC Number: 7887
• DSSTox Substance ID: DTXSID2062537
• Wikidata: Q27293343
• Mol file: 2582-30-1.mol

Synonyms:Aminoguanidine bicarbonate;2582-30-1;Aminoguanidine hydrogen carbonate;2200-97-7;Aminoguanidinium bicarbonate;2-aminoguanidine;carbonic acid;Aminoguanidine carbonate (1:1);Aminoguanidium hydrogen carbonate;N1-Aminoguanidine carbonate (1:1);Aminoguanidine carbonate;Aminoguanidinium hydrogen carbonate;1-Aminoguanidine bicarbonate;MFCD00012949;NSC 7887;EINECS 219-956-7;BA 51-090222;Guanidine, amino-, hydrogen carbonate;Ba 51-090222 (VAN);N(sup 1)-Aminoguanidine carbonate (1:1);AI3-52138;NSC7887;UNII-X2151435R9;amino(diaminomethylidene)azanium;hydrogen carbonate;Hydrazinecarboximidamide, carbonate (1:1);EC 219-956-7;Aminoguanidine hydrogencarbonate;2-aminoguanidine,carbonic acid;Hydrazinecarboximidamide carbonate;Amino guanidine bicarbonate;aminoguandine bicarbonate;CH6N4.CHO3;SCHEMBL40128;CH6N4.CH2O3;CH6N4.H2CO3;1-aminoguanidine;DTXSID2062537;Aminoguanidine bicarbonate, 97%;Amino guanidine hydrogen carbonate;C-H6-N4.C-H2-O3;N''-aminoguanidine;1-aminoguanidine carbonic acid salt;HB0111;AKOS015894487;AKOS015901290;hydrazinecarboximidamide bicarbonate salt;hydrazinecarboximidamide carbonic acid salt;LS-52066;A0307;F87308;Q27293343;[amino(hydrazinyl)methylidene]azanium hydrogen carbonate;F0001-0859;Carbonic acid compound with hydrazinecarboximidamide (1:1);Carbonic acid, compound with hydrazinecarboximidamide (1:1)

Chemical Property of Aminoguanidine bicarbonate

Chemical Property:

• Appearance/Colour: White to off-white crystalline powder
• Vapor Pressure: 2.56E-08mmHg at 25°C
• Melting Point: 170-172 °C (dec.)(lit.)
• Boiling Point: 422.4 °C at 760 mmHg
• PKA: 6.19[at 20 ℃]
• Flash Point: 209.3 °C
• PSA: 145.45000
• Density: 1,6 g/cm³
• LogP: 0.45680
• Storage Temp.: Store below +30°C.
• Solubility.: H2O: soluble2.7g/L at 20°C
• Water Solubility.: <5 g/L (20℃)
• Hydrogen Bond Donor Count: 5
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 0
• Exact Mass: 136.05964013
• Heavy Atom Count: 9
• Complexity: 67.9

Purity/Quality:

99% ^*data from raw suppliers

Aminoguanidine bicarbonate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn, Xi
• Hazard Codes: Xi,Xn,N
• Statements: 52/53-43-36/37/38-20/21/22-51/53
• Safety Statements: 22-24/25-37-24-36-26-36/37

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(=NN)(N)N.C(=O)(O)O
• Uses: Aminoguanidine bicarbonate (AGB) is of practical importance because of its use in dyes, dispersants, explosives and other commercial applications. It is used in the synthesis of antitumor agents and antileukemic activity. Also used in the synthesis of neuraminidase inhibitors in the inhibition of influenze.

Technology Process of Aminoguanidine bicarbonate

There total 6 articles about Aminoguanidine bicarbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

CYANAMID (420-04-2) + carbon dioxide (124-38-9,18923-20-1) → aminoguanidine bicarbonate (2582-30-1)

Guidance literature:

carbon dioxide; With water; hydrazine; at 20 - 55 ℃; for 1h; pH=7 - 11;

CYANAMID; carbon dioxide; In water; at 65 ℃; for 4h; pH=7; Product distribution / selectivity;

Reference yield: 86.0%

aminoguanidine hydroiodide (133082-93-6) + potassium hydrogencarbonate (298-14-6) → aminoguanidine bicarbonate (2582-30-1)

Guidance literature:

With carbon dioxide; In water;

DOI:10.1002/jlcr.1762

Reference yield: 80.0%

aminoguanidine hemisulfate salt (1068-42-4) + potassium hydrogencarbonate (298-14-6) → aminoguanidine bicarbonate (2582-30-1)

Guidance literature:

With carbon dioxide; In water;

DOI:10.1002/jlcr.1762

upstream raw materials:

nitroguanidine

CYANAMID

carbon dioxide

aminoguanidine hemisulfate salt

Downstream raw materials:

1,1'-(Aethylaethandiylidendinitrilo)-diguanidin

C₉H₁₂N₄O₂

C₈H₅F₅N₄

2,4-dinitrobenzaldehyde guanylhydrazone

Refernces

• 1、 Rane, Anil M.,Klaas, Schildknegt. "The synthesis of 5,7-dimethyl-1,2,4-triazolo[1,5a(14C)] pyrimidine-2-carbaldehyde from [14C]aminoguanidine: A key intermediate for the radiochemical GMP synthesis of a drug candidate". scheme or table. p. 257 - 260. Retrieved 2011/05/06.
• 2、 -. "1,5-disubstituted 7A-methylperhydroinden-3A-ol derivatives, useful in treating cardiovascular disorders, processes for their preparation and pharmaceutical compositions containing the same". . . Retrieved 2008/06/13.