3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[b]furan

Base Information

• Chemical Name: 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[b]furan
• CAS No.: 796851-30-4
• Molecular Formula: C14H17 B O3
• Molecular Weight: 244.098
• Hs Code.: 2934999090
• Mol file: 796851-30-4.mol

Synonyms:2-(Benzo[b]furan-3-yl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane

Chemical Property of 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[b]furan

Chemical Property:

• Vapor Pressure: 0.000174mmHg at 25°C
• Refractive Index: 1.54
• Boiling Point: 340°C at 760 mmHg
• Flash Point: 159.4°C
• PSA: 31.60000
• Density: 1.1g/cm³
• LogP: 2.73200
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Benzofuran-3-boronic acid pinacol ester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-(benzofuran-3-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane is useful reactant and reagent in organic reactions and synthesis.

Technology Process of 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[b]furan

There total 8 articles about 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[b]furan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2,3-dimethyl-2,3-butane diol (76-09-5) + benzofurane-3-ylboronic acid → 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-benzofuran (796851-30-4)

Guidance literature:

In diethyl ether; at 25 ℃; Inert atmosphere;

DOI:10.1002/anie.201810714

Reference yield: 77.0%

3-bromobenzofuran (59214-70-9) + bis(pinacol)diborane (73183-34-3) → 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-benzofuran (796851-30-4)

Guidance literature:

With C₅₄H₄₄NO₂PPdS; potassium acetate; In 2-methyltetrahydrofuran; at 90 ℃; for 24h; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.orglett.9b02414

Reference yield: 73.0%

3-chlorobenzofuran (63361-59-1) + bis(pinacol)diborane (73183-34-3) → 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-benzofuran (796851-30-4)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In toluene; at 120 ℃;

upstream raw materials:

3-bromobenzofuran

2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

1-benzofurane

bis(pinacol)diborane

Downstream raw materials:

3-methyl-benzofuran

tert-butyl (1S,2R)-2-(4-(benzofuran-3-yl)-2-(2,4-dimethoxybenzyl)-7-fluoro-3-oxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-6-ylamino)cyclohexylcarbamate

3-[3-bromo-2-(4-methoxy-benzyloxy)-phenyl]-2-hydroxy-2,3-dihydro-benzofuran-3-carboxylic acid methyl ester

3-[3-bromo-2-(4-methoxybenzyloxy)-phenyl]-3-methyl-benzofuran-2-one-3-carboxylate