(R)-1-[1-(2-cyanobenzyl)-5-(dimethylamino)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-7-yl]piperidine-3-tert-butyl carbamate

Base Information

Chemical Name:(R)-1-[1-(2-cyanobenzyl)-5-(dimethylamino)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-7-yl]piperidine-3-tert-butyl carbamate
CAS No.:1314947-07-3
Molecular Formula:C₂₇H₃₅N₇O₃
Molecular Weight:505.62
Hs Code.:

Synonyms:(R)-1-[1-(2-cyanobenzyl)-5-(dimethylamino)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-7-yl]piperidine-3-tert-butyl carbamate

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Chemical Property of (R)-1-[1-(2-cyanobenzyl)-5-(dimethylamino)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-7-yl]piperidine-3-tert-butyl carbamate

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Technology Process of (R)-1-[1-(2-cyanobenzyl)-5-(dimethylamino)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-7-yl]piperidine-3-tert-butyl carbamate

There total 12 articles about (R)-1-[1-(2-cyanobenzyl)-5-(dimethylamino)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-7-yl]piperidine-3-tert-butyl carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.1%

: 1314947-05-1
(R)-1-[5-(dimethylamino)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo [4,5-b]pyridin-7-yl]piperidine-3-tert-butyl carbamate

: 22115-41-9
2-(bromomethyl)benzonitrile

: 1314947-07-3
(R)-1-[1-(2-cyanobenzyl)-5-(dimethylamino)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-7-yl]piperidine-3-tert-butyl carbamate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at -10 - 20 ℃; for 3h;

Reference yield:

: 2897-43-0
2,6-dichloro-3-nitropyridin-4-amine

: 1314947-07-3
(R)-1-[1-(2-cyanobenzyl)-5-(dimethylamino)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-7-yl]piperidine-3-tert-butyl carbamate

Guidance literature:: Multi-step reaction with 7 steps

1: hydrogenchloride; sodium nitrite / water / 3 h / 0 - 25 °C

2: triethylamine / ethanol / 1 h / -10 °C

3: ethanol

4: ethanol; water / 24 h / 20 °C

5: ranay nickel / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

6: triethylamine / tetrahydrofuran / 0.5 h / -10 °C

7: potassium carbonate / N,N-dimethyl-formamide / 3 h / -10 - 20 °C

With hydrogenchloride; potassium carbonate; triethylamine; sodium nitrite; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 2587-00-0
2,6-dichloropyridine N-oxide

: 1314947-07-3
(R)-1-[1-(2-cyanobenzyl)-5-(dimethylamino)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-7-yl]piperidine-3-tert-butyl carbamate

Guidance literature:: Multi-step reaction with 11 steps

1.1: nitric acid; sulfuric acid / water / 1 h / 148 - 156 °C

1.2: pH 6

2.1: hydrogenchloride; iron / ethanol; water / 16 h / 95 °C

3.1: nitric acid; sulfuric acid / water / 1 h / 0 - 20 °C / Cooling with ice

4.1: sulfuric acid / water / 0.33 h / 100 °C

5.1: hydrogenchloride; sodium nitrite / water / 3 h / 0 - 25 °C

6.1: triethylamine / ethanol / 1 h / -10 °C

7.1: ethanol

8.1: ethanol; water / 24 h / 20 °C

9.1: ranay nickel / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

10.1: triethylamine / tetrahydrofuran / 0.5 h / -10 °C

11.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / -10 - 20 °C

With hydrogenchloride; sulfuric acid; nitric acid; iron; potassium carbonate; triethylamine; sodium nitrite; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;