4-[5-chloro-4-(4-cyano-6-trifluoromethyl-pyridin-3-yl)-2-(methyl-o-tolyl-carbamoyl)-phenoxy]-butyric acid

Base Information

Chemical Name:4-[5-chloro-4-(4-cyano-6-trifluoromethyl-pyridin-3-yl)-2-(methyl-o-tolyl-carbamoyl)-phenoxy]-butyric acid
CAS No.:1070890-41-3
Molecular Formula:C₂₆H₂₁ClF₃N₃O₄
Molecular Weight:531.919
Hs Code.:

Synonyms:4-[5-chloro-4-(4-cyano-6-trifluoromethyl-pyridin-3-yl)-2-(methyl-o-tolyl-carbamoyl)-phenoxy]-butyric acid

Suppliers and Price of 4-[5-chloro-4-(4-cyano-6-trifluoromethyl-pyridin-3-yl)-2-(methyl-o-tolyl-carbamoyl)-phenoxy]-butyric acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-[5-chloro-4-(4-cyano-6-trifluoromethyl-pyridin-3-yl)-2-(methyl-o-tolyl-carbamoyl)-phenoxy]-butyric acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-[5-chloro-4-(4-cyano-6-trifluoromethyl-pyridin-3-yl)-2-(methyl-o-tolyl-carbamoyl)-phenoxy]-butyric acid

There total 14 articles about 4-[5-chloro-4-(4-cyano-6-trifluoromethyl-pyridin-3-yl)-2-(methyl-o-tolyl-carbamoyl)-phenoxy]-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 35112-05-1
4-chloro-2-fluoro-5-nitro-benzoic acid

: 1070890-41-3
4-[5-chloro-4-(4-cyano-6-trifluoromethyl-pyridin-3-yl)-2-(methyl-o-tolyl-carbamoyl)-phenoxy]-butyric acid

Guidance literature:: Multi-step reaction with 10 steps

1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 2 h

2: triethylamine / dichloromethane / 12 h / 0 °C

3: sodium dithionite; water / tetrahydrofuran / 12 h

4: n-Butyl nitrite; copper(ll) bromide / acetonitrile / 2 h / 65 °C

5: methanol / 12 h / 55 °C

6: boron tribromide / dichloromethane / 12 h / -78 - 20 °C

7: potassium carbonate / N,N-dimethyl-formamide / 12 h / 60 °C

8: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 12 h / 95 °C

9: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 12 h / 100 °C

10: trifluoroacetic acid / dichloromethane / 2 h

With sodium dithionite; oxalyl dichloride; n-Butyl nitrite; water; potassium acetate; boron tribromide; sodium carbonate; potassium carbonate; triethylamine; trifluoroacetic acid; copper(ll) bromide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; N,N-dimethyl-formamide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1070892-55-5
4-[5-chloro-4-(4-cyano-6-trifluoromethyl-pyridin-3-yl)-2-(methyl-o-tolyl-carbamoyl)-phenoxy]-butyric acid tert-butyl ester

: 1070890-41-3
4-[5-chloro-4-(4-cyano-6-trifluoromethyl-pyridin-3-yl)-2-(methyl-o-tolyl-carbamoyl)-phenoxy]-butyric acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 2h;

Reference yield:

: 947311-91-3
4-chloro-2-fluoro-5-nitro-benzoyl chloride

: 1070890-41-3
4-[5-chloro-4-(4-cyano-6-trifluoromethyl-pyridin-3-yl)-2-(methyl-o-tolyl-carbamoyl)-phenoxy]-butyric acid

Guidance literature:: Multi-step reaction with 9 steps

1: triethylamine / dichloromethane / 12 h / 0 °C

2: sodium dithionite; water / tetrahydrofuran / 12 h

3: n-Butyl nitrite; copper(ll) bromide / acetonitrile / 2 h / 65 °C

4: methanol / 12 h / 55 °C

5: boron tribromide / dichloromethane / 12 h / -78 - 20 °C

6: potassium carbonate / N,N-dimethyl-formamide / 12 h / 60 °C

7: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 12 h / 95 °C

8: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 12 h / 100 °C

9: trifluoroacetic acid / dichloromethane / 2 h

With sodium dithionite; n-Butyl nitrite; water; potassium acetate; boron tribromide; sodium carbonate; potassium carbonate; triethylamine; trifluoroacetic acid; copper(ll) bromide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;