Technology Process of 4-[5-chloro-2-(methyl-o-tolyl-carbamoyl)-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenoxy]-butyric acid tert-butyl ester
There total 10 articles about 4-[5-chloro-2-(methyl-o-tolyl-carbamoyl)-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenoxy]-butyric acid tert-butyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 2 h
2: triethylamine / dichloromethane / 12 h / 0 °C
3: sodium dithionite; water / tetrahydrofuran / 12 h
4: n-Butyl nitrite; copper(ll) bromide / acetonitrile / 2 h / 65 °C
5: methanol / 12 h / 55 °C
6: boron tribromide / dichloromethane / 12 h / -78 - 20 °C
7: potassium carbonate / N,N-dimethyl-formamide / 12 h / 60 °C
8: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 12 h / 95 °C
With
sodium dithionite; oxalyl dichloride; n-Butyl nitrite; water; potassium acetate; boron tribromide; potassium carbonate; triethylamine; copper(ll) bromide;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N,N-dimethyl-formamide;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
- Guidance literature:
-
With
potassium acetate;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
1,4-dioxane;
at 95 ℃;
for 12h;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: triethylamine / dichloromethane / 12 h / 0 °C
2: sodium dithionite; water / tetrahydrofuran / 12 h
3: n-Butyl nitrite; copper(ll) bromide / acetonitrile / 2 h / 65 °C
4: methanol / 12 h / 55 °C
5: boron tribromide / dichloromethane / 12 h / -78 - 20 °C
6: potassium carbonate / N,N-dimethyl-formamide / 12 h / 60 °C
7: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 12 h / 95 °C
With
sodium dithionite; n-Butyl nitrite; water; potassium acetate; boron tribromide; potassium carbonate; triethylamine; copper(ll) bromide;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
