2-((4-methoxyphenyl)amino)-2-(naphthalen-2-yl)acetonitrile

Base Information

• Chemical Name: 2-((4-methoxyphenyl)amino)-2-(naphthalen-2-yl)acetonitrile
• CAS No.: 1404296-21-4
• Molecular Formula: C₁₉H₁₆N₂O
• Molecular Weight: 288.349
• Mol file: 1404296-21-4.mol

Synonyms:2-((4-methoxyphenyl)amino)-2-(naphthalen-2-yl)acetonitrile

Chemical Property of 2-((4-methoxyphenyl)amino)-2-(naphthalen-2-yl)acetonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-((4-methoxyphenyl)amino)-2-(naphthalen-2-yl)acetonitrile

There total 2 articles about 2-((4-methoxyphenyl)amino)-2-(naphthalen-2-yl)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2-naphthyl cyanohydrin (20862-03-7) + 4-methoxy-aniline (104-94-9) → 2-((4-methoxyphenyl)amino)-2-(naphthalen-2-yl)acetonitrile (1404296-21-4)

Guidance literature:

With titanium(IV) isopropylate; In toluene; at 40 ℃; for 18h; Inert atmosphere; Glovebox;

DOI:10.1039/c9cc08576a

Reference yield: 58.0%

trimethylsilyl cyanide (7677-24-9) + 4-methoxy-N-(naphth-2-ylmethyl)benzenamine (435274-63-8) → 2-((4-methoxyphenyl)amino)-2-(naphthalen-2-yl)acetonitrile (1404296-21-4)

Guidance literature:

With tert.-butylhydroperoxide; VO(OCH₃)(OC₆H₄CHNCH₂CH₂O); In acetonitrile; at 23 ℃; for 24h;

DOI:10.1016/j.tetlet.2013.11.012

Reference yield: 96.0%

2-((4-methoxyphenyl)amino)-2-(naphthalen-2-yl)acetonitrile (1404296-21-4) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → 1-(4-methoxyphenyl)-2-(naphthalen-2-yl)-5-oxopyrrolidine-2-carbonitrile

Guidance literature:

With tributylphosphine; In acetonitrile; at 30 ℃; for 0.5h; Inert atmosphere;

DOI:10.1055/a-1337-4684

upstream raw materials:

trimethylsilyl cyanide

4-methoxy-N-(naphth-2-ylmethyl)benzenamine

2-naphthyl cyanohydrin

4-methoxy-aniline

Downstream raw materials:

C₂₄H₂₂N₂O₃

methyl 2-({[cyano(naphthalen-2-yl)methyl](4-methoxyphenyl)amino}methyl)acrylate

1-(4-methoxyphenyl)-4-methylene-2-(naphthalen-2-yl)-5-oxopyrrolidine-2-carbonitrile