(R)-dimethyl 2-(4-((4-(hydroxymethyl)phenoxy)methyl)benzamido)pentanedioate

Base Information

Chemical Name:(R)-dimethyl 2-(4-((4-(hydroxymethyl)phenoxy)methyl)benzamido)pentanedioate
CAS No.:1346226-19-4
Molecular Formula:C₂₂H₂₅NO₇
Molecular Weight:415.443
Hs Code.:

Synonyms:(R)-dimethyl 2-(4-((4-(hydroxymethyl)phenoxy)methyl)benzamido)pentanedioate

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Chemical Property of (R)-dimethyl 2-(4-((4-(hydroxymethyl)phenoxy)methyl)benzamido)pentanedioate

Chemical Property:

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Technology Process of (R)-dimethyl 2-(4-((4-(hydroxymethyl)phenoxy)methyl)benzamido)pentanedioate

There total 3 articles about (R)-dimethyl 2-(4-((4-(hydroxymethyl)phenoxy)methyl)benzamido)pentanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 623-05-2
(4-hydroxyphenyl)methanol

: 1346225-93-1
(R)-dimethyl 2-(4-(chloromethyl)benzamido)pentanedioate

: 1346226-19-4
(R)-dimethyl 2-(4-((4-(hydroxymethyl)phenoxy)methyl)benzamido)pentanedioate

Guidance literature:: With potassium carbonate; potassium iodide; In acetonitrile; at 70 ℃; for 5h;
DOI:10.1016/j.ejmech.2011.09.017

Reference yield:

: 1642-81-5
p-(chloromethyl)benzoic acid

: 1346226-19-4
(R)-dimethyl 2-(4-((4-(hydroxymethyl)phenoxy)methyl)benzamido)pentanedioate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 4-methyl-morpholine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane; N,N-dimethyl-formamide / 0.5 h / 20 °C

1.2: 20 °C

2.1: potassium carbonate; potassium iodide / acetonitrile / 5 h / 70 °C

With 4-methyl-morpholine; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; potassium iodide; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.ejmech.2011.09.017

Reference yield:

: 13515-99-6,23150-65-4,27025-25-8
D-glutamic acid dimethyl ester hydrochloride

: 1346226-19-4
(R)-dimethyl 2-(4-((4-(hydroxymethyl)phenoxy)methyl)benzamido)pentanedioate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 4-methyl-morpholine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane; N,N-dimethyl-formamide / 0.5 h / 20 °C

1.2: 20 °C

2.1: potassium carbonate; potassium iodide / acetonitrile / 5 h / 70 °C

With 4-methyl-morpholine; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; potassium iodide; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.ejmech.2011.09.017