Technology Process of 5-Bromo-3-phenylimidazo[1,5-a]pyridine
There total 7 articles about 5-Bromo-3-phenylimidazo[1,5-a]pyridine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
N-((6-bromopyridin-2-yl)-methyl)benzamide;
With
2-methoxypyridine; trifluoromethylsulfonic anhydride;
In
dichloromethane;
for 0.0333333h;
Inert atmosphere;
In
dichloromethane;
at 50 ℃;
for 16h;
Inert atmosphere;
DOI:10.1021/acs.joc.6b02928
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1,1'-azodicarbonyl-dipiperidine; triphenylphosphine / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere
2: hydrazine hydrate / ethanol / Heating
3: triethylamine / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere
4: 2-methoxypyridine; trifluoromethylsulfonic anhydride / dichloromethane / 16 h / 50 °C / Inert atmosphere
With
2-methoxypyridine; trifluoromethylsulfonic anhydride; hydrazine hydrate; triethylamine; triphenylphosphine; 1,1'-azodicarbonyl-dipiperidine;
In
tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/ol400870b
- Guidance literature:
-
Multi-step reaction with 3 steps
1: hydrazine hydrate / ethanol / Heating
2: triethylamine / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere
3: 2-methoxypyridine; trifluoromethylsulfonic anhydride / dichloromethane / 16 h / 50 °C / Inert atmosphere
With
2-methoxypyridine; trifluoromethylsulfonic anhydride; hydrazine hydrate; triethylamine;
In
ethanol; dichloromethane;
DOI:10.1021/ol400870b
