Glycine, N-[(4-amino-1-methyl-1H-pyrrol-2-yl)carbonyl]-, methyl ester (9CI)

Base Information

• Chemical Name: Glycine, N-[(4-amino-1-methyl-1H-pyrrol-2-yl)carbonyl]-, methyl ester (9CI)
• CAS No.: 794529-77-4
• Molecular Formula: C₉H₁₃N₃O₃
• Molecular Weight: 211.221
• Mol file: 794529-77-4.mol

Synonyms:Glycine, N-[(4-amino-1-methyl-1H-pyrrol-2-yl)carbonyl]-, methyl ester (9CI)

Chemical Property of Glycine, N-[(4-amino-1-methyl-1H-pyrrol-2-yl)carbonyl]-, methyl ester (9CI)

Chemical Property:

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MSDS Files:

SDS file from LookChem

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Technology Process of Glycine, N-[(4-amino-1-methyl-1H-pyrrol-2-yl)carbonyl]-, methyl ester (9CI)

There total 2 articles about Glycine, N-[(4-amino-1-methyl-1H-pyrrol-2-yl)carbonyl]-, methyl ester (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[(1-methyl-4-nitro-1H-pyrrole-2-carbonyl)-amino]-acetic acid methyl ester (861959-95-7) → [(4-amino-1-methyl-1H-pyrrole-2-carbonyl)-amino]-acetic acid methyl ester (794529-77-4)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 2h; under 2585.74 Torr;

DOI:10.1016/j.ejmech.2005.02.005

Reference yield:

1-methyl-4-nitro-2-trichloroacetylpyrrole (120122-47-6) → [(4-amino-1-methyl-1H-pyrrole-2-carbonyl)-amino]-acetic acid methyl ester (794529-77-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: Et₃N / CH₂Cl₂ / 0.5 h

1.2: 84 percent / CH₂Cl₂ / 24 h

2.1: H₂ / Pd/C / CH₂Cl₂ / 18 h / 20 °C

With hydrogen; triethylamine; palladium on activated charcoal; In dichloromethane;

DOI:10.1080/10426500701418299

Reference yield: 50.0%

[(4-amino-1-methyl-1H-pyrrole-2-carbonyl)-amino]-acetic acid methyl ester (794529-77-4) + phenyl N,N-bis(2-chloroethyl)phosphoramidochloridate (4798-75-8) → [(4-O-phenyl-N-(bis-2-chloroethyl)-phosphoramidic-1-methyl-1H-pyrrole-2-carbonyl)-amino]-acetic acid methyl ester (1100748-51-3)

Guidance literature:

With triethylamine; at -10 ℃; for 24h;

DOI:10.3184/030823408X34996

upstream raw materials:

[(1-methyl-4-nitro-1H-pyrrole-2-carbonyl)-amino]-acetic acid methyl ester

1-methyl-4-nitro-2-trichloroacetylpyrrole

Downstream raw materials:

({4-[4-(4-{(2S)-2-[bis(ethylsulfanyl)methyl]pyrrolidine-1-carbonyl}-2-methoxy-5-nitrophenoxy)butyrylamino]-1-methyl-1H-pyrrole-2-carbonyl}amino)acetic acid methyl ester

({4-[4-(4-{(2S)-2-[bis(ethylsulfanyl)methyl]pyrrolidine-1-carbonyl}-2-methoxy-5-nitrophenoxy)butyrylamino]-1-methyl-1H-pyrrole-2-carbonyl}amino)acetic acid

C₅₂H₇₃N₉O₁₄S₄

[(4-O-phenyl-N-(bis-2-chloroethyl)-phosphoramidic-1-methyl-1H-pyrrole-2-carbonyl)-amino]-acetic acid methyl ester

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