phenyl bis(2-chloroethyl)phosphoramidochloridate

Base Information

• Chemical Name: phenyl bis(2-chloroethyl)phosphoramidochloridate
• CAS No.: 4798-75-8
• Molecular Formula: C10H13 Cl3 N O2 P
• Molecular Weight: 316.551
• Mol file: 4798-75-8.mol

Synonyms:Phosphoramidochloridicacid, bis(2-chloroethyl)-, phenyl ester (7CI,8CI,9CI); NSC 67778

Chemical Property of phenyl bis(2-chloroethyl)phosphoramidochloridate

Chemical Property:

• Vapor Pressure: 3.79E-06mmHg at 25°C
• Boiling Point: 385.5°C at 760 mmHg
• Flash Point: 186.9°C
• Density: 1.385g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of phenyl bis(2-chloroethyl)phosphoramidochloridate

There total 5 articles about phenyl bis(2-chloroethyl)phosphoramidochloridate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

bis-(2-chloroethyl)amine hydrochloride (821-48-7) + O-phenyl phosphorodichloridate (770-12-7) → phenyl N,N-bis(2-chloroethyl)phosphoramidochloridate (4798-75-8)

Guidance literature:

With triethylamine; In dichloromethane; Ambient temperature;

Reference yield: 75.0%

N,N-di(2-chloroethyl)amidophosphoric acid dichloride (127-88-8) + phenol (108-95-2,27073-41-2) → phenyl N,N-bis(2-chloroethyl)phosphoramidochloridate (4798-75-8)

Guidance literature:

N,N-di(2-chloroethyl)amidophosphoric acid dichloride; phenol; In toluene; at 0 ℃; for 0.333333h;

With triethylamine; In toluene; at 20 ℃; for 9h; Reflux;

DOI:10.3184/030823410X12790414891526

Reference yield:

N,N-di(2-chloroethyl)amidophosphoric acid dichloride (127-88-8) + bis-(2-chloroethyl)amine hydrochloride (821-48-7) + phenol (108-95-2,27073-41-2) → phenyl N,N-bis(2-chloroethyl)phosphoramidochloridate (4798-75-8)

Guidance literature:

With triethylamine; In phosphorus (III) oxychloride; toluene;

upstream raw materials:

N,N-di(2-chloroethyl)amidophosphoric acid dichloride

phenol

bis-(2-chloroethyl)amine hydrochloride

O-phenyl phosphorodichloridate

Downstream raw materials:

N,N-bis-(2-chloro-ethyl)-P-morpholin-4-yl-phosphonamidic acid phenyl ester

N,N-bis-(2-chloro-ethyl)-N'-(4-methyl-thiazol-2-yl)-phosphorodiamidic acid phenyl ester

N,N-bis-(2-chloro-ethyl)-N'-(4-thiazol-2-ylsulfamoyl-phenyl)-phosphorodiamidic acid phenyl ester

C₂₀H₃₂Cl₂N₃O₄P