benzyl (2R,4S,5S)-5-(tert-butoxycarbonyl)amino-4-hydroxy-6-phenyl-1-(4-(pyridin-2-yl)phenyl)hexan-2-ylcarbamate

Base Information

Chemical Name:benzyl (2R,4S,5S)-5-(tert-butoxycarbonyl)amino-4-hydroxy-6-phenyl-1-(4-(pyridin-2-yl)phenyl)hexan-2-ylcarbamate
CAS No.:854753-97-2
Molecular Formula:C₃₆H₄₁N₃O₅
Molecular Weight:595.739
Hs Code.:

Synonyms:benzyl (2R,4S,5S)-5-(tert-butoxycarbonyl)amino-4-hydroxy-6-phenyl-1-(4-(pyridin-2-yl)phenyl)hexan-2-ylcarbamate

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Chemical Property of benzyl (2R,4S,5S)-5-(tert-butoxycarbonyl)amino-4-hydroxy-6-phenyl-1-(4-(pyridin-2-yl)phenyl)hexan-2-ylcarbamate

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Technology Process of benzyl (2R,4S,5S)-5-(tert-butoxycarbonyl)amino-4-hydroxy-6-phenyl-1-(4-(pyridin-2-yl)phenyl)hexan-2-ylcarbamate

There total 3 articles about benzyl (2R,4S,5S)-5-(tert-butoxycarbonyl)amino-4-hydroxy-6-phenyl-1-(4-(pyridin-2-yl)phenyl)hexan-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 854753-94-9
(4S,5S)-5-(tert-butoxycarbonylamino)-4-(tert-butyldimethylsilyloxy)-6-phenyl-2-(4-(pyridin-2-yl)benzyl)hexanoic acid

: 100-51-6,185532-71-2
benzyl alcohol

: 854753-97-2
benzyl (2R,4S,5S)-5-(tert-butoxycarbonyl)amino-4-hydroxy-6-phenyl-1-(4-(pyridin-2-yl)phenyl)hexan-2-ylcarbamate

: 854753-96-1
benzyl (2S,4S,5S)-5-(tert-butoxycarbonyl)amino-4-hydroxy-6-phenyl-1-(4-(pyridin-2-yl)phenyl)hexan-2-ylcarbamate

Guidance literature:: (4S,5S)-5-(tert-butoxycarbonylamino)-4-(tert-butyldimethylsilyloxy)-6-phenyl-2-(4-(pyridin-2-yl)benzyl)hexanoic acid; With diphenyl phosphoryl azide; triethylamine; In toluene; for 2h; Heating / reflux;

benzyl alcohol; In toluene; for 16h; Heating / reflux;

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 25 ℃; for 40h;

Reference yield: 38.0%

: [4-tert-butoxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-5-phenyl-1-(4-pyridin-2-yl-benzyl)-pentyl]-carbamic acid benzyl ester

: 854753-97-2
benzyl (2R,4S,5S)-5-(tert-butoxycarbonyl)amino-4-hydroxy-6-phenyl-1-(4-(pyridin-2-yl)phenyl)hexan-2-ylcarbamate

: 854753-96-1
benzyl (2S,4S,5S)-5-(tert-butoxycarbonyl)amino-4-hydroxy-6-phenyl-1-(4-(pyridin-2-yl)phenyl)hexan-2-ylcarbamate

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 40h; optical yield given as %de; Inert atmosphere;
DOI:10.1021/jm900044w

Reference yield: 23.0%

: 854753-94-9
(4S,5S)-5-(tert-butoxycarbonylamino)-4-(tert-butyldimethylsilyloxy)-6-phenyl-2-(4-(pyridin-2-yl)benzyl)hexanoic acid

: 100-51-6,185532-71-2
benzyl alcohol

: 854753-97-2
benzyl (2R,4S,5S)-5-(tert-butoxycarbonyl)amino-4-hydroxy-6-phenyl-1-(4-(pyridin-2-yl)phenyl)hexan-2-ylcarbamate

Guidance literature:: (4S,5S)-5-(tert-butoxycarbonylamino)-4-(tert-butyldimethylsilyloxy)-6-phenyl-2-(4-(pyridin-2-yl)benzyl)hexanoic acid; benzyl alcohol; In toluene; for 16h; Heating / reflux;

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 25 ℃; for 40h;