(4S,5S)-5-(tert-butoxycarbonylamino)-4-(tert-butyldimethylsilyloxy)-6-phenyl-2-(4-(pyridin-2-yl)benzyl)hexanoic acid

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Chemical Name:(4S,5S)-5-(tert-butoxycarbonylamino)-4-(tert-butyldimethylsilyloxy)-6-phenyl-2-(4-(pyridin-2-yl)benzyl)hexanoic acid
CAS No.:854753-94-9
Molecular Formula:C₃₅H₄₈N₂O₅Si
Molecular Weight:604.862
Hs Code.:

Synonyms:(4S,5S)-5-(tert-butoxycarbonylamino)-4-(tert-butyldimethylsilyloxy)-6-phenyl-2-(4-(pyridin-2-yl)benzyl)hexanoic acid

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Chemical Property of (4S,5S)-5-(tert-butoxycarbonylamino)-4-(tert-butyldimethylsilyloxy)-6-phenyl-2-(4-(pyridin-2-yl)benzyl)hexanoic acid

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Technology Process of (4S,5S)-5-(tert-butoxycarbonylamino)-4-(tert-butyldimethylsilyloxy)-6-phenyl-2-(4-(pyridin-2-yl)benzyl)hexanoic acid

There total 1 articles about (4S,5S)-5-(tert-butoxycarbonylamino)-4-(tert-butyldimethylsilyloxy)-6-phenyl-2-(4-(pyridin-2-yl)benzyl)hexanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 854753-93-8
{1-[5-oxo-4-(4-pyridin-2-ylbenzyl)tetrahydrofuran-2-yl]-2-phenylethyl}carbamic acid tert-butyl ester

: 18162-48-6
tert-butyldimethylsilyl chloride

: 854753-94-9
(4S,5S)-5-(tert-butoxycarbonylamino)-4-(tert-butyldimethylsilyloxy)-6-phenyl-2-(4-(pyridin-2-yl)benzyl)hexanoic acid

Guidance literature:: {1-[5-oxo-4-(4-pyridin-2-ylbenzyl)tetrahydrofuran-2-yl]-2-phenylethyl}carbamic acid tert-butyl ester; With sodium hydroxide; water; In 1,4-dioxane; at 25 ℃; for 0.5h;

With hydrogenchloride; In water; at 0 ℃; pH=5;

tert-butyldimethylsilyl chloride; With 1H-imidazole; hydrogenchloride; more than 3 stages;

Reference yield: 38.0%

: 854753-94-9
(4S,5S)-5-(tert-butoxycarbonylamino)-4-(tert-butyldimethylsilyloxy)-6-phenyl-2-(4-(pyridin-2-yl)benzyl)hexanoic acid

: 100-51-6,185532-71-2
benzyl alcohol

: 854753-97-2
benzyl (2R,4S,5S)-5-(tert-butoxycarbonyl)amino-4-hydroxy-6-phenyl-1-(4-(pyridin-2-yl)phenyl)hexan-2-ylcarbamate

: 854753-96-1
benzyl (2S,4S,5S)-5-(tert-butoxycarbonyl)amino-4-hydroxy-6-phenyl-1-(4-(pyridin-2-yl)phenyl)hexan-2-ylcarbamate

Guidance literature:: (4S,5S)-5-(tert-butoxycarbonylamino)-4-(tert-butyldimethylsilyloxy)-6-phenyl-2-(4-(pyridin-2-yl)benzyl)hexanoic acid; With diphenyl phosphoryl azide; triethylamine; In toluene; for 2h; Heating / reflux;

benzyl alcohol; In toluene; for 16h; Heating / reflux;

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 25 ℃; for 40h;

Reference yield: 23.0%

: 854753-94-9
(4S,5S)-5-(tert-butoxycarbonylamino)-4-(tert-butyldimethylsilyloxy)-6-phenyl-2-(4-(pyridin-2-yl)benzyl)hexanoic acid

: 100-51-6,185532-71-2
benzyl alcohol

: 854753-97-2
benzyl (2R,4S,5S)-5-(tert-butoxycarbonyl)amino-4-hydroxy-6-phenyl-1-(4-(pyridin-2-yl)phenyl)hexan-2-ylcarbamate

Guidance literature:: (4S,5S)-5-(tert-butoxycarbonylamino)-4-(tert-butyldimethylsilyloxy)-6-phenyl-2-(4-(pyridin-2-yl)benzyl)hexanoic acid; benzyl alcohol; In toluene; for 16h; Heating / reflux;

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 25 ℃; for 40h;