N-(tert-butoxycarbonyl)-L-leucyl-L-γ-O-benzylglutamyl-L-γ-O-benzylglutamyl-L-leucine methyl ester

Base Information

• Chemical Name: N-(tert-butoxycarbonyl)-L-leucyl-L-γ-O-benzylglutamyl-L-γ-O-benzylglutamyl-L-leucine methyl ester
• CAS No.: 77302-69-3
• Molecular Formula: C₄₂H₆₀N₄O₁₁
• Molecular Weight: 796.959
• Mol file: 77302-69-3.mol

Synonyms:N-(tert-butoxycarbonyl)-L-leucyl-L-γ-O-benzylglutamyl-L-γ-O-benzylglutamyl-L-leucine methyl ester

Chemical Property of N-(tert-butoxycarbonyl)-L-leucyl-L-γ-O-benzylglutamyl-L-γ-O-benzylglutamyl-L-leucine methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(tert-butoxycarbonyl)-L-leucyl-L-γ-O-benzylglutamyl-L-γ-O-benzylglutamyl-L-leucine methyl ester

There total 19 articles about N-(tert-butoxycarbonyl)-L-leucyl-L-γ-O-benzylglutamyl-L-γ-O-benzylglutamyl-L-leucine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-tert-butoxycarbonyl-L-leucine (13139-15-6,53296-34-7) + (S)-2-[(S)-2-((R)-2-Amino-4-benzyloxycarbonyl-butyrylamino)-4-benzyloxycarbonyl-butyrylamino]-4-methyl-pentanoic acid methyl ester; hydrochloride (77302-68-2) → (S)-2-{(S)-4-Benzyloxycarbonyl-2-[(R)-4-benzyloxycarbonyl-2-((S)-2-tert-butoxycarbonylamino-4-methyl-pentanoylamino)-butyrylamino]-butyrylamino}-4-methyl-pentanoic acid methyl ester (77302-69-3,77302-93-3,77302-94-4)

Guidance literature:

With 4-methyl-morpholine; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane; at 0 - 20 ℃; for 22h;

DOI:10.1021/jm00138a013

Reference yield:

N-tert-butoxycarbonyl-L-leucine (13139-15-6,53296-34-7) + (S)-2-[(S)-2-((S)-2-Amino-4-benzyloxycarbonyl-butyrylamino)-4-benzyloxycarbonyl-butyrylamino]-4-methyl-pentanoic acid methyl ester; hydrochloride (77302-68-2) → N-(tert-butoxycarbonyl)-L-leucyl-L-γ-O-benzylglutamyl-L-γ-O-benzylglutamyl-L-leucine methyl ester (77302-69-3)

Guidance literature:

With 4-methyl-morpholine; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane; at 0 - 20 ℃; for 22h; Yield given;

DOI:10.1021/jm00138a013

Reference yield:

N-tert-butoxycarbonyl-L-leucine (13139-15-6,53296-34-7) + (S)-2-[(R)-2-((R)-2-Amino-4-benzyloxycarbonyl-butyrylamino)-4-benzyloxycarbonyl-butyrylamino]-4-methyl-pentanoic acid methyl ester; hydrochloride (77302-68-2) → (S)-2-{(R)-4-Benzyloxycarbonyl-2-[(R)-4-benzyloxycarbonyl-2-((S)-2-tert-butoxycarbonylamino-4-methyl-pentanoylamino)-butyrylamino]-butyrylamino}-4-methyl-pentanoic acid methyl ester (77302-69-3,77302-93-3,77302-94-4)

Guidance literature:

With 4-methyl-morpholine; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane; at 0 - 20 ℃; for 22h;

DOI:10.1021/jm00138a013

upstream raw materials:

N-tert-butoxycarbonyl-L-leucine

(S)-2-[(R)-2-((R)-2-Amino-4-benzyloxycarbonyl-butyrylamino)-4-benzyloxycarbonyl-butyrylamino]-4-methyl-pentanoic acid methyl ester; hydrochloride

N-(tert-butyloxycarbonyl)-γ-benzyl-D-glutamic acid

(S)-2-[(R)-4-Benzyloxycarbonyl-2-((R)-4-benzyloxycarbonyl-2-tert-butoxycarbonylamino-butyrylamino)-butyrylamino]-4-methyl-pentanoic acid methyl ester

Downstream raw materials:

Boc-Phe-Leu-D-Glu-D-Glu-Leu-OMe

(S)-2-((R)-4-Benzyloxycarbonyl-2-{(R)-4-benzyloxycarbonyl-2-[(S)-2-((S)-2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-4-methyl-pentanoylamino]-butyrylamino}-butyrylamino)-4-methyl-pentanoic acid methyl ester

Boc-Phe-Leu-D-Glu-Glu-Leu-OMe

(S)-2-((S)-4-Benzyloxycarbonyl-2-{(R)-4-benzyloxycarbonyl-2-[(S)-2-((S)-2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-4-methyl-pentanoylamino]-butyrylamino}-butyrylamino)-4-methyl-pentanoic acid methyl ester