(4S,5S)-1-(tert-Butyloxycarbonyl)-4-hydroxy-5-<<3-(benzyloxymethyl)imidazol-4-yl>methyl>pyrrolidin-2-one

Base Information

Chemical Name:(4S,5S)-1-(tert-Butyloxycarbonyl)-4-hydroxy-5-<<3-(benzyloxymethyl)imidazol-4-yl>methyl>pyrrolidin-2-one
CAS No.:120742-09-8
Molecular Formula:C₂₁H₂₇N₃O₅
Molecular Weight:401.462
Hs Code.:

Synonyms:(4S,5S)-1-(tert-Butyloxycarbonyl)-4-hydroxy-5-<<3-(benzyloxymethyl)imidazol-4-yl>methyl>pyrrolidin-2-one

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Chemical Property of (4S,5S)-1-(tert-Butyloxycarbonyl)-4-hydroxy-5-<<3-(benzyloxymethyl)imidazol-4-yl>methyl>pyrrolidin-2-one

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Technology Process of (4S,5S)-1-(tert-Butyloxycarbonyl)-4-hydroxy-5-<<3-(benzyloxymethyl)imidazol-4-yl>methyl>pyrrolidin-2-one

There total 3 articles about (4S,5S)-1-(tert-Butyloxycarbonyl)-4-hydroxy-5-<<3-(benzyloxymethyl)imidazol-4-yl>methyl>pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 120742-08-7
(S)-2-(3-Benzyloxymethyl-3H-imidazol-4-ylmethyl)-3-hydroxy-5-oxo-2,5-dihydro-pyrrole-1-carboxylic acid tert-butyl ester

: 120742-09-8
(4S,5S)-1-(tert-Butyloxycarbonyl)-4-hydroxy-5-<<3-(benzyloxymethyl)imidazol-4-yl>methyl>pyrrolidin-2-one

Guidance literature:: With sodium tetrahydroborate; acetic acid; In dichloromethane; at 0 ℃; for 4h; Yield given;
DOI:10.1021/jm00127a028

Reference yield:

: 79950-65-5,99310-01-7
N-[(1,1-dimethylethoxy)carbonyl]-3-[(phenylmethoxy)methyl]-L-histidine

: 120742-09-8
(4S,5S)-1-(tert-Butyloxycarbonyl)-4-hydroxy-5-<<3-(benzyloxymethyl)imidazol-4-yl>methyl>pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: DMAP, DCC / CH₂Cl₂ / 24 h / Ambient temperature

2: acetonitrile / 0.5 h / 110 deg C bath temperature

3: NaBH₄, acetic acid / CH₂Cl₂ / 4 h / 0 °C

With dmap; sodium tetrahydroborate; acetic acid; dicyclohexyl-carbodiimide; In dichloromethane; acetonitrile;
DOI:10.1021/jm00127a028

Reference yield:

: 120742-07-6
5-<1-Hydroxy-2(S)-<(tert-butyloxycarbonyl)amino>-3-<3-(benzyloxymethyl)imidazol-4-yl>propylidene>-2,2-dimethyl-1,3-dioxane-4,6-dione

: 120742-09-8
(4S,5S)-1-(tert-Butyloxycarbonyl)-4-hydroxy-5-<<3-(benzyloxymethyl)imidazol-4-yl>methyl>pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: acetonitrile / 0.5 h / 110 deg C bath temperature

2: NaBH₄, acetic acid / CH₂Cl₂ / 4 h / 0 °C

With sodium tetrahydroborate; acetic acid; In dichloromethane; acetonitrile;
DOI:10.1021/jm00127a028