1-isopropyl-7-((2-(4-(4-methylpiperazin-1-yl)phenylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)ethynyl)-1H-indole-3-carbonitrile

Base Information

Chemical Name:1-isopropyl-7-((2-(4-(4-methylpiperazin-1-yl)phenylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)ethynyl)-1H-indole-3-carbonitrile
CAS No.:1147015-04-0
Molecular Formula:C₃₁H₃₀N₈
Molecular Weight:514.633
Hs Code.:

Synonyms:1-isopropyl-7-((2-(4-(4-methylpiperazin-1-yl)phenylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)ethynyl)-1H-indole-3-carbonitrile

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Chemical Property of 1-isopropyl-7-((2-(4-(4-methylpiperazin-1-yl)phenylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)ethynyl)-1H-indole-3-carbonitrile

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Technology Process of 1-isopropyl-7-((2-(4-(4-methylpiperazin-1-yl)phenylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)ethynyl)-1H-indole-3-carbonitrile

There total 10 articles about 1-isopropyl-7-((2-(4-(4-methylpiperazin-1-yl)phenylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)ethynyl)-1H-indole-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

: 1142946-17-5
⁽⁰⁸¹⁾C₀₇₅₀₅

: 1147015-02-8
7-ethynyl-1-isopropyl-1H-indole-3-carbonitrile

: 1147015-04-0
1-isopropyl-7-((2-(4-(4-methylpiperazin-1-yl)phenylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)ethynyl)-1H-indole-3-carbonitrile

Guidance literature:: With triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In N,N-dimethyl-formamide; at 80 ℃; for 1h;

Reference yield:

: 51417-51-7
7-bromo-1H-indole

: 1147015-04-0
1-isopropyl-7-((2-(4-(4-methylpiperazin-1-yl)phenylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)ethynyl)-1H-indole-3-carbonitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.75 h / 20 °C

1.2: 18 h

2.1: trichlorophosphate / 0.08 h / 0 °C

2.2: 1.5 h / 90 °C

2.3: 0 °C

3.1: hydroxylamine hydrochloride / 4 h / 150 °C

4.1: triethylamine / bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / N,N-dimethyl-formamide / 2 h / 80 °C

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran

6.1: triethylamine / bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / N,N-dimethyl-formamide / 1 h / 80 °C

With hydroxylamine hydrochloride; tetrabutyl ammonium fluoride; sodium hydride; triethylamine; trichlorophosphate; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 16153-81-4
4-(4-Methyl-piperazino)-anilin

: 1147015-04-0
1-isopropyl-7-((2-(4-(4-methylpiperazin-1-yl)phenylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)ethynyl)-1H-indole-3-carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: N,N-dimethyl-formamide / 17 h / 20 °C

2.1: trifluoroacetic acid / dichloromethane / 17 h / 20 °C

2.2: 0.5 h / 160 °C / Microwave irradiation

3.1: trichlorophosphate / 0.33 h / 120 °C

3.2: 0 °C / pH 9 - 10

4.1: triethylamine / bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / N,N-dimethyl-formamide / 1 h / 80 °C

With triethylamine; trifluoroacetic acid; trichlorophosphate; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In dichloromethane; N,N-dimethyl-formamide;