1142946-17-5

Basic information

• Product Name: 7H-Pyrrolo[2,3-d]pyriMidin-2-aMine, 4-chloro-N-[4-(4-Methyl-1-piperazinyl)phenyl]-
• Synonyms: 7H-Pyrrolo[2,3-d]pyriMidin-2-aMine, 4-chloro-N-[4-(4-Methyl-1-piperazinyl)phenyl]-;4-Chloro-N-(4-(4-methylpiperazin-1-yl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine
• CAS NO: 1142946-17-5
• Molecular Formula: C₁₇H₁₉ClN₆
• Molecular Weight: 342.82596
• Mol File: 1142946-17-5.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Density: 1.373±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 12.22±0.50(Predicted)
• CAS DataBase Reference: 7H-Pyrrolo[2,3-d]pyriMidin-2-aMine, 4-chloro-N-[4-(4-Methyl-1-piperazinyl)phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 7H-Pyrrolo[2,3-d]pyriMidin-2-aMine, 4-chloro-N-[4-(4-Methyl-1-piperazinyl)phenyl]-(1142946-17-5)
• EPA Substance Registry System: 7H-Pyrrolo[2,3-d]pyriMidin-2-aMine, 4-chloro-N-[4-(4-Methyl-1-piperazinyl)phenyl]-(1142946-17-5)

Safety Data

• Hazardous Substances Data: 1142946-17-5(Hazardous Substances Data)

Usage

General Description

7H-Pyrrolo[2,3-d]pyrimidin-2-amine, 4-chloro-N-[4-(4-methyl-1-piperazinyl)phenyl]- is a chemical compound with potential pharmaceutical applications. It is a pyrimidine derivative with an amine group and a chloro-substituted phenyl ring attached to the nitrogen atom. The compound also contains a piperazine ring with a methyl group. This chemical structure indicates potential biological activity and pharmacological properties, making it a candidate for drug development and research in the field of medicinal chemistry. Further studies and experiments are needed to fully evaluate its potential therapeutic uses.

Upstream product

• 1142946-16-4 2-(4-(4-methylpiperazin-1-yl)phenylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-ol 
• 16153-81-4 4-(4-Methyl-piperazino)-anilin 
• 52133-67-2 ethyl 2-cyano-4,4-diethoxybutyrate 
• 1143571-97-4 (Z)-tert-butyl (tert-butoxycarbonylamino)(4-(4-methylpiperazin-1-yl)phenylamino)methylenecarbamate 

Downstream Products

• 1142947-92-9 4-chloro-N-(4-(4-methylpiperazin-1-yl)phenyl)-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-2-amine 
• 1142946-18-6 5-(2-(4-(4-methylpiperazin-1-yl)phenylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)thiophene-2-carbaldehyde 
• 1142946-20-0 5-(2-(4-(4-methylpiperazin-1-yl)phenylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)thiophene-2-carbonitrile 
• 1142946-21-1 5-(2-(4-(4-methylpiperazin-1-yl)phenylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)thiophene-2-carboxylic acid 
• 1142947-94-1 tert-butyl 2-(2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-carboxylate 
• 1142947-46-3 2-(2-(4-(4-methylpiperazin-1-yl)phenylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)benzo[b]thiophene-6-carbonitrile 
• 1142946-54-0 2-(2-(4-(4-methylpiperazin-1-yl)phenylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)thiophene-3-carbonitrile 
• 1142947-23-6 [4-(4-methyl-piperazin-1-yl)-phenyl]-[4-(4-phenyl-thiophen-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-amine 
• 1142947-24-7 {4-[4-(3-isopropyl-phenyl)-thiophen-2-yl]-7H-pyrrolo[2,3-d]pyrimidin-2-yl}-[4-(4-methyl-piperazin-1-yl)-phenyl]-amine 
• 1142947-26-9 C₃₁H₃₃N₇O₃S₂ 
• 1147015-24-4 4-{[2-methyl-1-(1-methylethyl)-1H-benzimidazol-7-yl]ethynyl}-N-[4-(4-methylpiperazin-1-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-2-amine 
• 1147015-04-0 1-isopropyl-7-((2-(4-(4-methylpiperazin-1-yl)phenylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)ethynyl)-1H-indole-3-carbonitrile 
• 1147014-90-1 N-(4-(4-methylpiperazin-1-yl)phenyl)-4-(2-o-tolylethynyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine 

Relevant articles and documents

PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USE AS JANUS KINASE MODULATORS

Provided herein are pyrrolopyrimidine compounds of Formula (I) wherein R1 is a heteroaryl containing at least one S atom, and optionally substituted on a ring carbon by one, two, or three substituents each independently selected from the group consisting of : halo, hydroxyl, nitro, formyl, formamido, cyano, sulfonyl, carboxy, amino, amido, acylamino, carbamoyl, sulphamoyl, alkyl, alkenyl, CF3, ureido, alkynyl, alkoxy, alkanoyl, alkoxycarbonyl, carbaldehyde oxime, N -alkylsulphamoyl, N-alkylcarbamoyl, -OR13R11 or -R13R11; R2 is phenyl or pyridinyl, wherein R2 optionally substituted on a ring carbon by one, two, or three substituents each indenpendently selected from the group consisting of : halo, hydroxyl, cyano, nitro, formyl, formamido, carboxy, sulfonyl, amino, amido, -N- alkyl -amino, carbamoyl, sulphamoyl, CF3, ureido, alkyl, alkenyl, alkynyl, alkoxy, alkanoyl, alkoxycarbonyl, N-alkylsulphamoyl, N-alkylcarbamoyl, -OR11, -OR12R11, or -R12R11; and methods of making and using the same. Such compounds may be used in inflammatory or myeloproliferative disorders. The disclosure also provides for treating cancer.