4-chloro-2-[4-(4-methylphenyl)-2,3-dihydro-1,3-thiazol-2-ylidene]-3-oxobutanenitrile

Base Information

• Chemical Name: 4-chloro-2-[4-(4-methylphenyl)-2,3-dihydro-1,3-thiazol-2-ylidene]-3-oxobutanenitrile
• CAS No.: 439133-50-3
• Molecular Formula: C₁₄H₁₁ClN₂OS
• Molecular Weight: 290.773

Synonyms:4-chloro-2-[4-(4-methylphenyl)-2,3-dihydro-1,3-thiazol-2-ylidene]-3-oxobutanenitrile

Chemical Property of 4-chloro-2-[4-(4-methylphenyl)-2,3-dihydro-1,3-thiazol-2-ylidene]-3-oxobutanenitrile

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Technology Process of 4-chloro-2-[4-(4-methylphenyl)-2,3-dihydro-1,3-thiazol-2-ylidene]-3-oxobutanenitrile

There total 1 articles about 4-chloro-2-[4-(4-methylphenyl)-2,3-dihydro-1,3-thiazol-2-ylidene]-3-oxobutanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

chloroacetyl chloride (79-04-9) + 4-(4-methylphenyl)-2-thiazolylacetonitrile (250579-91-0) → 4-chloro-2-[4-(4-methylphenyl)-2,3-dihydro-1,3-thiazol-2-ylidene]-3-oxobutanenitrile (439133-50-3)

Guidance literature:

With pyridine; In 1,4-dioxane; at 100 ℃; for 0.666667h;

DOI:10.1002/1099-0690(200202)2002:4<663::AID-EJOC663>3.0.CO;2-A

Reference yield: 80.0%

3-methoxybenzoic hydrazide (5785-06-8) + 4-chloro-2-[4-(4-methylphenyl)-2,3-dihydro-1,3-thiazol-2-ylidene]-3-oxobutanenitrile (439133-50-3) → N-[5-amino-3-oxo-4-(4-p-tolyl-thiazol-2-yl)-2,3-dihydro-pyrrol-1-yl]-3-methoxy-benzamide

Guidance literature:

In N,N-dimethyl-formamide; at 110 - 120 ℃; for 2h;

DOI:10.1002/1099-0690(200202)2002:4<663::AID-EJOC663>3.0.CO;2-A

Reference yield: 80.0%

o-nitrobenzohydrazide (606-26-8) + 4-chloro-2-[4-(4-methylphenyl)-2,3-dihydro-1,3-thiazol-2-ylidene]-3-oxobutanenitrile (439133-50-3) → N-[5-amino-3-oxo-4-(4-p-tolyl-thiazol-2-yl)-2,3-dihydro-pyrrol-1-yl]-2-nitro-benzamide

Guidance literature:

In N,N-dimethyl-formamide; at 110 - 120 ℃; for 2h;

DOI:10.1002/1099-0690(200202)2002:4<663::AID-EJOC663>3.0.CO;2-A

upstream raw materials:

chloroacetyl chloride

4-(4-methylphenyl)-2-thiazolylacetonitrile

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