873657-15-9

Basic information

• Product Name: 3-(tert-butyldimethylsiloxy)ethyl-1-(4-chlorobenzoyl)-5-methoxy-2-methylindole
• Synonyms: 3-(tert-butyldimethylsiloxy)ethyl-1-(4-chlorobenzoyl)-5-methoxy-2-methylindole
• CAS NO: 873657-15-9
• Molecular Weight: 458.072
• Mol File: 873657-15-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(tert-butyldimethylsiloxy)ethyl-1-(4-chlorobenzoyl)-5-methoxy-2-methylindole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(tert-butyldimethylsiloxy)ethyl-1-(4-chlorobenzoyl)-5-methoxy-2-methylindole(873657-15-9)
• EPA Substance Registry System: 3-(tert-butyldimethylsiloxy)ethyl-1-(4-chlorobenzoyl)-5-methoxy-2-methylindole(873657-15-9)

Safety Data

• Hazardous Substances Data: 873657-15-9(Hazardous Substances Data)

Upstream product

• 191348-14-8 2-iodo-4-methoxylaniline 
• 122-01-0 4-chloro-benzoyl chloride 
• 873657-14-8 N-(4-chlorobenzoyl)-2-iodo-4-methoxyaniline 

Downstream Products

• 53-86-1 [1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid 
• 24438-49-1 <1-(4-chlorobenzoyl)-2-methyl-5-methoxyindol-3-yl>acetaldehyde 
• 16130-32-8 (4-chlorophenyl)(3-(2-hydroxyethyl)-5-methoxy-2-methyl-1H-indol-1-yl)methanone 

Relevant articles and documents

A new entry to the synthesis of 2,3-disubstituted indoles

(Chemical Equation Presented) The Stille coupling of N-acyl-2-iodoanilines with the 1-(tributylstannyl)-1-substituted allenes affected the successive one-step formation of the 2-methyl-3-substituted indoles. Alternatively, the other type of 2-alkyl-3-substituted indoles could be synthesized in a one-pot operation, which consists of the Stille coupling reaction with the 1-(tributylstannyl)-1,3-disubstituted allenes, followed by TBAF treatment. This procedure could be applied to the synthesis of indomethacin.