2-((2S,3S)-1-(4-Methoxy-phenyl)-2-{[(E)-4-methoxy-phenylimino]-methyl}-4-oxo-azetidin-3-yl)-isoindole-1,3-dione

Base Information

• Chemical Name: 2-((2S,3S)-1-(4-Methoxy-phenyl)-2-{[(E)-4-methoxy-phenylimino]-methyl}-4-oxo-azetidin-3-yl)-isoindole-1,3-dione
• CAS No.: 136137-17-2
• Molecular Formula: C₂₆H₂₁N₃O₅
• Molecular Weight: 455.47

Synonyms:2-((2S,3S)-1-(4-Methoxy-phenyl)-2-{[(E)-4-methoxy-phenylimino]-methyl}-4-oxo-azetidin-3-yl)-isoindole-1,3-dione

Chemical Property of 2-((2S,3S)-1-(4-Methoxy-phenyl)-2-{[(E)-4-methoxy-phenylimino]-methyl}-4-oxo-azetidin-3-yl)-isoindole-1,3-dione

Chemical Property:

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Technology Process of 2-((2S,3S)-1-(4-Methoxy-phenyl)-2-{[(E)-4-methoxy-phenylimino]-methyl}-4-oxo-azetidin-3-yl)-isoindole-1,3-dione

There total 6 articles about 2-((2S,3S)-1-(4-Methoxy-phenyl)-2-{[(E)-4-methoxy-phenylimino]-methyl}-4-oxo-azetidin-3-yl)-isoindole-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-phthaloylglycine chloride (6780-38-7) + 1,4-bis(4'-methoxyphenyl)-1,4-diazabuta-1,3-diene (24978-42-5,24764-91-8) → 2-((2S,3S)-1-(4-Methoxy-phenyl)-2-{[(E)-4-methoxy-phenylimino]-methyl}-4-oxo-azetidin-3-yl)-isoindole-1,3-dione (136137-17-2)

Guidance literature:

With triethylamine; In toluene; Ambient temperature;

DOI:10.1021/jo00048a027

Reference yield:

N-phthaloylglycine chloride (6780-38-7) → 2-((2S,3S)-1-(4-Methoxy-phenyl)-2-{[(E)-4-methoxy-phenylimino]-methyl}-4-oxo-azetidin-3-yl)-isoindole-1,3-dione (136137-17-2)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / CH₂Cl₂ / Ambient temperature

2: 1) O₃, 2) O₂, methyl sulfide / 1) CH₂Cl₂, -78 deg C

3: 4.16 g / CH₂Cl₂ / 4 h / molecular sieves

With dimethylsulfide; oxygen; ozone; triethylamine; In dichloromethane;

DOI:10.1016/S0040-4020(01)80972-8

Reference yield:

(E)-4-methoxy-N-((E)-3-phenylallylidene)aniline (88315-63-3) → 2-((2S,3S)-1-(4-Methoxy-phenyl)-2-{[(E)-4-methoxy-phenylimino]-methyl}-4-oxo-azetidin-3-yl)-isoindole-1,3-dione (136137-17-2)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / CH₂Cl₂ / Ambient temperature

2: 1) O₃, 2) O₂, methyl sulfide / 1) CH₂Cl₂, -78 deg C

3: 4.16 g / CH₂Cl₂ / 4 h / molecular sieves

With dimethylsulfide; oxygen; ozone; triethylamine; In dichloromethane;

DOI:10.1016/S0040-4020(01)80972-8

upstream raw materials:

N-phthaloylglycine chloride

1,4-bis(4'-methoxyphenyl)-1,4-diazabuta-1,3-diene

(2R*,3R*)-3-(1,3-dioxoisoindolin-2-yl)-1-(4-methoxyphenyl)-4-oxoazetidine-2-carbaldehyde

4-methoxy-aniline

Downstream raw materials:

1-p-methoxyphenyl-3-phthalimido-4-(1'-p-methoxyphenyl-3'-phenyl-azetidin-2'-one-4'-yl)-azetidin-2-one

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