5-O-(Dimethoxytrityl)-2-deoxy-1-β-<5-methyl-2-oxo-(3H)pyrimido<1,6-a>perimidin-3-yl>-3-O-ribofuranosylphosphonate triethylammonium salt

Base Information

Chemical Name:5-O-(Dimethoxytrityl)-2-deoxy-1-β-<5-methyl-2-oxo-(3H)pyrimido<1,6-a>perimidin-3-yl>-3-O-ribofuranosylphosphonate triethylammonium salt
CAS No.:119680-18-1
Molecular Formula:C₆H₁₅N*C₄₁H₃₈N₃O₈P
Molecular Weight:832.934
Hs Code.:

Synonyms:5-O-(Dimethoxytrityl)-2-deoxy-1-β-<5-methyl-2-oxo-(3H)pyrimido<1,6-a>perimidin-3-yl>-3-O-ribofuranosylphosphonate triethylammonium salt

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-O-(Dimethoxytrityl)-2-deoxy-1-β-<5-methyl-2-oxo-(3H)pyrimido<1,6-a>perimidin-3-yl>-3-O-ribofuranosylphosphonate triethylammonium salt

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 5-O-(Dimethoxytrityl)-2-deoxy-1-β-<5-methyl-2-oxo-(3H)pyrimido<1,6-a>perimidin-3-yl>-3-O-ribofuranosylphosphonate triethylammonium salt

There total 6 articles about 5-O-(Dimethoxytrityl)-2-deoxy-1-β-<5-methyl-2-oxo-(3H)pyrimido<1,6-a>perimidin-3-yl>-3-O-ribofuranosylphosphonate triethylammonium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 119680-07-8
5-Methyl-3-(3,5-di-O-acetyl-2-deoxy-1-β-D-ribofuranosyl)pyrimido-<1,6-a>perimidin-2(3H)-one

: 119680-18-1
5-O-(Dimethoxytrityl)-2-deoxy-1-β-<5-methyl-2-oxo-(3H)pyrimido<1,6-a>perimidin-3-yl>-3-O-ribofuranosylphosphonate triethylammonium salt

Guidance literature:: Multi-step reaction with 3 steps

1: 38percent aq. NH₃ / methanol; tetrahydrofuran / 24 h / Ambient temperature

2: pyridine / 48 h

3: 1.) N-methylmorpholine, 1,2,4-triazole, PCl₃ / CH₂Cl₂, 1.) room temp., 1 h, 2.) -78 deg C to 0 deg C

With 4-methyl-morpholine; pyridine; 1,2,4-Triazole; ammonium hydroxide; phosphorus trichloride; In tetrahydrofuran; methanol;
DOI:10.1021/ja00190a044

Reference yield:

: 119680-05-6
3',5'-Di-O-acetyl-4-O-<(2,4,6-triisopropylphenyl)sulfonyl>thymidine

: 119680-18-1
5-O-(Dimethoxytrityl)-2-deoxy-1-β-<5-methyl-2-oxo-(3H)pyrimido<1,6-a>perimidin-3-yl>-3-O-ribofuranosylphosphonate triethylammonium salt

Guidance literature:: Multi-step reaction with 4 steps

1: 78 percent / tetrahydrofuran / 24 h / Heating

2: 38percent aq. NH₃ / methanol; tetrahydrofuran / 24 h / Ambient temperature

3: pyridine / 48 h

4: 1.) N-methylmorpholine, 1,2,4-triazole, PCl₃ / CH₂Cl₂, 1.) room temp., 1 h, 2.) -78 deg C to 0 deg C

With 4-methyl-morpholine; pyridine; 1,2,4-Triazole; ammonium hydroxide; phosphorus trichloride; In tetrahydrofuran; methanol;
DOI:10.1021/ja00190a044

Reference yield:

: 479-27-6
naphthalene-1,8-diamine

: 119680-18-1
5-O-(Dimethoxytrityl)-2-deoxy-1-β-<5-methyl-2-oxo-(3H)pyrimido<1,6-a>perimidin-3-yl>-3-O-ribofuranosylphosphonate triethylammonium salt

Guidance literature:: Multi-step reaction with 4 steps

1: 78 percent / tetrahydrofuran / 24 h / Heating

2: 38percent aq. NH₃ / methanol; tetrahydrofuran / 24 h / Ambient temperature

3: pyridine / 48 h

4: 1.) N-methylmorpholine, 1,2,4-triazole, PCl₃ / CH₂Cl₂, 1.) room temp., 1 h, 2.) -78 deg C to 0 deg C

With 4-methyl-morpholine; pyridine; 1,2,4-Triazole; ammonium hydroxide; phosphorus trichloride; In tetrahydrofuran; methanol;
DOI:10.1021/ja00190a044