(R)-2-{20-[(R)-1-Hydroxymethyl-2-(4-methoxy-benzyloxy)-ethoxy]-icosa-9,11-diynyloxy}-3-(4-methoxy-benzyloxy)-propan-1-ol

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Chemical Name:(R)-2-{20-[(R)-1-Hydroxymethyl-2-(4-methoxy-benzyloxy)-ethoxy]-icosa-9,11-diynyloxy}-3-(4-methoxy-benzyloxy)-propan-1-ol
CAS No.:609848-04-6
Molecular Formula:C₄₂H₆₂O₈
Molecular Weight:694.949
Hs Code.:

Synonyms:(R)-2-{20-[(R)-1-Hydroxymethyl-2-(4-methoxy-benzyloxy)-ethoxy]-icosa-9,11-diynyloxy}-3-(4-methoxy-benzyloxy)-propan-1-ol

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Chemical Property of (R)-2-{20-[(R)-1-Hydroxymethyl-2-(4-methoxy-benzyloxy)-ethoxy]-icosa-9,11-diynyloxy}-3-(4-methoxy-benzyloxy)-propan-1-ol

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Technology Process of (R)-2-{20-[(R)-1-Hydroxymethyl-2-(4-methoxy-benzyloxy)-ethoxy]-icosa-9,11-diynyloxy}-3-(4-methoxy-benzyloxy)-propan-1-ol

There total 4 articles about (R)-2-{20-[(R)-1-Hydroxymethyl-2-(4-methoxy-benzyloxy)-ethoxy]-icosa-9,11-diynyloxy}-3-(4-methoxy-benzyloxy)-propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 609848-03-5
C₈₀H₉₀O₈

: 609848-04-6
(R)-2-{20-[(R)-1-Hydroxymethyl-2-(4-methoxy-benzyloxy)-ethoxy]-icosa-9,11-diynyloxy}-3-(4-methoxy-benzyloxy)-propan-1-ol

Guidance literature:: With toluene-4-sulfonic acid; In methanol; chloroform; at 20 ℃; for 4h;
DOI:10.1055/s-2002-32987

Reference yield:

: 220641-23-6
1-O-(triphenylmethyl)-3-O-(4'-methoxybenzyl)-sn-glycerol

: 609848-04-6
(R)-2-{20-[(R)-1-Hydroxymethyl-2-(4-methoxy-benzyloxy)-ethoxy]-icosa-9,11-diynyloxy}-3-(4-methoxy-benzyloxy)-propan-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 99 percent / NaH; TBAI / dimethylformamide / 19 h / 20 °C

2: 93 percent / CuCl; O₂; TMEDA / acetone / 15 h / 60 °C

3: 86 percent / p-TsOH / CHCl₃; methanol / 4 h / 20 °C

With N,N,N,N,-tetramethylethylenediamine; oxygen; tetra-(n-butyl)ammonium iodide; sodium hydride; toluene-4-sulfonic acid; copper(l) chloride; In methanol; chloroform; N,N-dimethyl-formamide; acetone; 2: Glaser acetylene coupling;
DOI:10.1055/s-2002-32987

Reference yield:

: 119227-71-3
9-decynyl mesylate

: 609848-04-6
(R)-2-{20-[(R)-1-Hydroxymethyl-2-(4-methoxy-benzyloxy)-ethoxy]-icosa-9,11-diynyloxy}-3-(4-methoxy-benzyloxy)-propan-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 99 percent / NaH; TBAI / dimethylformamide / 19 h / 20 °C

2: 93 percent / CuCl; O₂; TMEDA / acetone / 15 h / 60 °C

3: 86 percent / p-TsOH / CHCl₃; methanol / 4 h / 20 °C

With N,N,N,N,-tetramethylethylenediamine; oxygen; tetra-(n-butyl)ammonium iodide; sodium hydride; toluene-4-sulfonic acid; copper(l) chloride; In methanol; chloroform; N,N-dimethyl-formamide; acetone; 2: Glaser acetylene coupling;
DOI:10.1055/s-2002-32987