6,6-Difluorobicyclo[3.1.0]hexane-3-carboxylic acid

Base Information

Chemical Name:6,6-Difluorobicyclo[3.1.0]hexane-3-carboxylic acid
CAS No.:1093751-02-0
Molecular Formula:C₇H₈F₂O₂
Molecular Weight:162.136
Hs Code.:
DSSTox Substance ID:DTXSID801230214
Mol file:1093751-02-0.mol

Synonyms:6,6-DIFLUOROBICYCLO[3.1.0]HEXANE-3-CARBOXYLIC ACID;1093751-02-0;C7H8F2O2;SCHEMBL4022933;SCHEMBL15116895;IOQVITCQIHHDBC-UHFFFAOYSA-N;6,6-DIFLUORO-BICYCLO[3.1.0]HEXANE-3-CARBOXYLIC ACID;DTXSID801230214;AMY35062;MFCD15526993;AKOS026716804;AB70682;SB17535;AS-42348;CS-0050368;EN300-178552;6,6-Ddifluorobicyclo[3.1.0]hexane-3-carboxylic acid;F2147-4005;6,6-Difluorobicyclo[3.1.0]hexane-3-carboxylic acid, 95%;6,6-DIFLUOROBICYCLO[3.1.0]HEXANE-3-CARBOXYLICACID

Suppliers and Price of 6,6-Difluorobicyclo[3.1.0]hexane-3-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
6,6-Difluorobicyclo[3.1.0]hexane-3-carboxylicAcid
100mg
$ 330.00

Labseeker
6,6-Difluoro-bicyclo[3.1.0]hexane-3-carboxylicacid 95
500mg
$ 800.00

Crysdot
6,6-Difluorobicyclo[3.1.0]hexane-3-carboxylicacid 95+%
1g
$ 857.00

Chemenu
6,6-difluorobicyclo[3.1.0]hexane-3-carboxylicacid 95%+
1g
$ 825.00

American Custom Chemicals Corporation
6,6-DIFLUOROBICYCLO[3.1.0]HEXANE-3-CARBOXYLIC ACID 95.00%
5MG
$ 458.05

Activate Scientific
6,6-Difluorobicyclo[3.1.0]hexane-3-carboxylic acid 97%
250 mg
$ 423.00

Activate Scientific
6,6-Difluorobicyclo[3.1.0]hexane-3-carboxylic acid 97%
100 mg
$ 207.00

Total 10 raw suppliers

Chemical Property of 6,6-Difluorobicyclo[3.1.0]hexane-3-carboxylic acid

Chemical Property:

XLogP3:1.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:162.04923582
Heavy Atom Count:11
Complexity:201

Purity/Quality:

97% ^*data from raw suppliers

6,6-Difluorobicyclo[3.1.0]hexane-3-carboxylicAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1C(CC2C1C2(F)F)C(=O)O

Technology Process of 6,6-Difluorobicyclo[3.1.0]hexane-3-carboxylic acid

There total 2 articles about 6,6-Difluorobicyclo[3.1.0]hexane-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 58101-60-3
methyl cyclopent-3-ene-1-carboxylate

: 1093751-02-0,1447942-40-6
6,6-difluorobicyclo[3.1.0]hexane-3-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: diethylene glycol dimethyl ether / 160 °C

2.1: lithium hydroxide monohydrate; water / tetrahydrofuran; methanol / 16 h / 20 °C

2.2: pH 6

With lithium hydroxide monohydrate; water; In tetrahydrofuran; methanol; diethylene glycol dimethyl ether;

Reference yield:

: 1093750-99-2
methyl 6,6-difluorobicyclo[3.1.0]hexane-3-carboxylate

: 1093751-02-0,1447942-40-6
6,6-difluorobicyclo[3.1.0]hexane-3-carboxylic acid

Guidance literature:: methyl 6,6-difluorobicyclo[3.1.0]hexane-3-carboxylate; With lithium hydroxide monohydrate; water; In tetrahydrofuran; methanol; at 20 ℃; for 16h;

With hydrogenchloride; In water; pH=6;

Reference yield:

: 1093751-02-0,1447942-40-6
6,6-difluorobicyclo[3.1.0]hexane-3-carboxylic acid

: 1093751-05-3
cis-3-(4-chlorophenyl)-2-(6,6-difluorobicyclo[3.1.0]hexan-3-yl)-6-methylpyrimidin-4(3H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl dichloride / dichloromethane / 20 °C

2.1: pyridine / chloroform / 16 h / Reflux

3.1: trimethylaluminum / hexane; 1,2-dichloro-ethane / 0.5 h / 20 °C / Inert atmosphere

3.2: 16 h / 90 °C

With pyridine; oxalyl dichloride; trimethylaluminum; In hexane; dichloromethane; chloroform; 1,2-dichloro-ethane;