cis-3-(4-chlorophenyl)-2-(6,6-difluorobicyclo[3.1.0]hexan-3-yl)-6-methylpyrimidin-4(3H)-one

Base Information

Chemical Name:cis-3-(4-chlorophenyl)-2-(6,6-difluorobicyclo[3.1.0]hexan-3-yl)-6-methylpyrimidin-4(3H)-one
CAS No.:1093751-05-3
Molecular Formula:C₁₇H₁₅ClF₂N₂O
Molecular Weight:336.769
Hs Code.:

Synonyms:cis-3-(4-chlorophenyl)-2-(6,6-difluorobicyclo[3.1.0]hexan-3-yl)-6-methylpyrimidin-4(3H)-one

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Chemical Property of cis-3-(4-chlorophenyl)-2-(6,6-difluorobicyclo[3.1.0]hexan-3-yl)-6-methylpyrimidin-4(3H)-one

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Technology Process of cis-3-(4-chlorophenyl)-2-(6,6-difluorobicyclo[3.1.0]hexan-3-yl)-6-methylpyrimidin-4(3H)-one

There total 4 articles about cis-3-(4-chlorophenyl)-2-(6,6-difluorobicyclo[3.1.0]hexan-3-yl)-6-methylpyrimidin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 58101-60-3
methyl cyclopent-3-ene-1-carboxylate

: 1093751-05-3
cis-3-(4-chlorophenyl)-2-(6,6-difluorobicyclo[3.1.0]hexan-3-yl)-6-methylpyrimidin-4(3H)-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: diethylene glycol dimethyl ether / 160 °C

2.1: lithium hydroxide monohydrate; water / tetrahydrofuran; methanol / 16 h / 20 °C

2.2: pH 6

3.1: oxalyl dichloride / dichloromethane / 20 °C

4.1: pyridine / chloroform / 16 h / Reflux

5.1: trimethylaluminum / hexane; 1,2-dichloro-ethane / 0.5 h / 20 °C / Inert atmosphere

5.2: 16 h / 90 °C

With pyridine; oxalyl dichloride; lithium hydroxide monohydrate; water; trimethylaluminum; In tetrahydrofuran; methanol; hexane; dichloromethane; chloroform; diethylene glycol dimethyl ether; 1,2-dichloro-ethane;

Reference yield:

: 1093750-99-2
methyl 6,6-difluorobicyclo[3.1.0]hexane-3-carboxylate

: 1093751-05-3
cis-3-(4-chlorophenyl)-2-(6,6-difluorobicyclo[3.1.0]hexan-3-yl)-6-methylpyrimidin-4(3H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium hydroxide monohydrate; water / tetrahydrofuran; methanol / 16 h / 20 °C

1.2: pH 6

2.1: oxalyl dichloride / dichloromethane / 20 °C

3.1: pyridine / chloroform / 16 h / Reflux

4.1: trimethylaluminum / hexane; 1,2-dichloro-ethane / 0.5 h / 20 °C / Inert atmosphere

4.2: 16 h / 90 °C

With pyridine; oxalyl dichloride; lithium hydroxide monohydrate; water; trimethylaluminum; In tetrahydrofuran; methanol; hexane; dichloromethane; chloroform; 1,2-dichloro-ethane;

Reference yield:

: 1093751-02-0,1447942-40-6
6,6-difluorobicyclo[3.1.0]hexane-3-carboxylic acid

: 1093751-05-3
cis-3-(4-chlorophenyl)-2-(6,6-difluorobicyclo[3.1.0]hexan-3-yl)-6-methylpyrimidin-4(3H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl dichloride / dichloromethane / 20 °C

2.1: pyridine / chloroform / 16 h / Reflux

3.1: trimethylaluminum / hexane; 1,2-dichloro-ethane / 0.5 h / 20 °C / Inert atmosphere

3.2: 16 h / 90 °C

With pyridine; oxalyl dichloride; trimethylaluminum; In hexane; dichloromethane; chloroform; 1,2-dichloro-ethane;