Technology Process of (3R,4R,5S)-1-allyl-3,4-bis(benzyloxy)-5-(difluoro(phenylthio)methyl)-5-hydroxypyrrolidin-2-one
There total 7 articles about (3R,4R,5S)-1-allyl-3,4-bis(benzyloxy)-5-(difluoro(phenylthio)methyl)-5-hydroxypyrrolidin-2-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tetrabutylammonium triphenyldifluorosilicate;
In
N,N-dimethyl-formamide;
at -78 ℃;
for 8h;
Temperature;
DOI:10.1021/jo301327s
- Guidance literature:
-
Multi-step reaction with 6 steps
1: acetyl chloride / 4 h / Reflux
2: dichloromethane / 5 h / 0 °C / Reflux
3: acetyl chloride / 5 h / Reflux
4: ammonium cerium (IV) nitrate / water; acetonitrile / 4 h / 0 - 20 °C
5: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 16 h / 0 - 20 °C
6: tetrabutylammonium triphenyldifluorosilicate / N,N-dimethyl-formamide / 8 h / -78 °C
With
ammonium cerium (IV) nitrate; di-isopropyl azodicarboxylate; acetyl chloride; triphenylphosphine; tetrabutylammonium triphenyldifluorosilicate;
In
tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo301327s
- Guidance literature:
-
Multi-step reaction with 7 steps
1: lithium hydroxide monohydrate; water / ethanol / 24 h / 0 °C
2: acetyl chloride / 4 h / Reflux
3: dichloromethane / 5 h / 0 °C / Reflux
4: acetyl chloride / 5 h / Reflux
5: ammonium cerium (IV) nitrate / water; acetonitrile / 4 h / 0 - 20 °C
6: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 16 h / 0 - 20 °C
7: tetrabutylammonium triphenyldifluorosilicate / N,N-dimethyl-formamide / 8 h / -78 °C
With
ammonium cerium (IV) nitrate; lithium hydroxide monohydrate; di-isopropyl azodicarboxylate; water; acetyl chloride; triphenylphosphine; tetrabutylammonium triphenyldifluorosilicate;
In
tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo301327s
