C₃₀H₂₁N₅O₂

Base Information

• Chemical Name: C₃₀H₂₁N₅O₂
• CAS No.: 1201646-95-8
• Molecular Formula: C₃₀H₂₁N₅O₂
• Molecular Weight: 483.529
• Mol file: 1201646-95-8.mol

Synonyms:C₃₀H₂₁N₅O₂

Chemical Property of C₃₀H₂₁N₅O₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₀H₂₁N₅O₂

There total 8 articles about C₃₀H₂₁N₅O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 3.0%

oxalyl dichloride (79-37-8) + 2-(4-((3'-amino[3,6'-biquinolin]-4'-yl)amino)phenyl)-2-methyl propanenitrile (1201646-92-5) → C29H21N5 (1201646-94-7) + C30H21N5O2 (1201646-95-8)

Guidance literature:

2-(4-((3'-amino[3,6'-biquinolin]-4'-yl)amino)phenyl)-2-methyl propanenitrile; With dmap; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 0.5h;

oxalyl dichloride; In tetrahydrofuran; at 0 ℃; for 3h;

With potassium tert-butylate; In tetrahydrofuran; Reflux;

Reference yield:

(E)-5-bromo-2-((2-nitrovinyl)amino)benzoic acid (1201643-75-5) → C29H21N5 (1201646-94-7) + C30H21N5O2 (1201646-95-8)

Guidance literature:

Multi-step reaction with 7 steps

1.1: potassium acetate / acetic anhydride / 1.5 h / 120 °C

2.1: potassium acetate / bis-triphenylphosphine-palladium(II) chloride / dimethyl sulfoxide / 80 °C / Inert atmosphere

3.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane / 80 °C / Inert atmosphere

4.1: N-ethyl-N,N-diisopropylamine; trichlorophosphate / acetonitrile / 0 - 80 °C

5.1: acetic acid / 4 h / 20 °C / Inert atmosphere

6.1: hydrogen / Ra-Ni / tetrahydrofuran; methanol / 3 h / 1551.49 Torr

7.1: dmap; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.5 h / 20 °C

7.2: 3 h / 0 °C

7.3: Reflux

With dmap; hydrogen; potassium acetate; sodium carbonate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; bis-triphenylphosphine-palladium(II) chloride; Ra-Ni; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; acetic anhydride; acetic acid; dimethyl sulfoxide; acetonitrile;

Reference yield:

6-bromo-3-nitroquinolin-4-ol (853908-50-6) → C29H21N5 (1201646-94-7) + C30H21N5O2 (1201646-95-8)

Guidance literature:

Multi-step reaction with 6 steps

1.1: potassium acetate / bis-triphenylphosphine-palladium(II) chloride / dimethyl sulfoxide / 80 °C / Inert atmosphere

2.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane / 80 °C / Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine; trichlorophosphate / acetonitrile / 0 - 80 °C

4.1: acetic acid / 4 h / 20 °C / Inert atmosphere

5.1: hydrogen / Ra-Ni / tetrahydrofuran; methanol / 3 h / 1551.49 Torr

6.1: dmap; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.5 h / 20 °C

6.2: 3 h / 0 °C

6.3: Reflux

With dmap; hydrogen; potassium acetate; sodium carbonate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; bis-triphenylphosphine-palladium(II) chloride; Ra-Ni; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; acetic acid; dimethyl sulfoxide; acetonitrile;

upstream raw materials:

oxalyl dichloride

2-(4-((3'-amino[3,6'-biquinolin]-4'-yl)amino)phenyl)-2-methyl propanenitrile

(E)-5-bromo-2-((2-nitrovinyl)amino)benzoic acid

C₁₅H₁₇BN₂O₅