2-(1-(4-fluorophenyl)-2-(methylsulfonyl)ethyl)-N-(5-methyl-1H-pyrazol-3-yl)quinazolin-4-amine

Base Information

Chemical Name:2-(1-(4-fluorophenyl)-2-(methylsulfonyl)ethyl)-N-(5-methyl-1H-pyrazol-3-yl)quinazolin-4-amine
CAS No.:1241916-14-2
Molecular Formula:C₂₁H₂₀FN₅O₂S
Molecular Weight:425.487
Hs Code.:

Synonyms:2-(1-(4-fluorophenyl)-2-(methylsulfonyl)ethyl)-N-(5-methyl-1H-pyrazol-3-yl)quinazolin-4-amine

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Chemical Property of 2-(1-(4-fluorophenyl)-2-(methylsulfonyl)ethyl)-N-(5-methyl-1H-pyrazol-3-yl)quinazolin-4-amine

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Technology Process of 2-(1-(4-fluorophenyl)-2-(methylsulfonyl)ethyl)-N-(5-methyl-1H-pyrazol-3-yl)quinazolin-4-amine

There total 6 articles about 2-(1-(4-fluorophenyl)-2-(methylsulfonyl)ethyl)-N-(5-methyl-1H-pyrazol-3-yl)quinazolin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 40137-11-9
diethyl methylsulfonylmethylphosphonate

: 1241914-71-5
(4-fluorophenyl)(4-(5-methyl-1H-pyrazol-3-ylamino)quinazolin-2-yl)methanone

: 1241916-14-2
2-(1-(4-fluorophenyl)-2-(methylsulfonyl)ethyl)-N-(5-methyl-1H-pyrazol-3-yl)quinazolin-4-amine

Guidance literature:: diethyl methylsulfonylmethylphosphonate; With potassium tert-butylate; In tetrahydrofuran; at 0 ℃; for 0.0833333h;

(4-fluorophenyl)(4-(5-methyl-1H-pyrazol-3-ylamino)quinazolin-2-yl)methanone; In tetrahydrofuran; at 20 ℃; for 4h;

With hydrogen; palladium 10% on activated carbon; In ethyl acetate; at 20 ℃;

Reference yield:

: 34632-69-4
ethyl 4-chloro-quinazoline-2-carboxylate

: 1241916-14-2
2-(1-(4-fluorophenyl)-2-(methylsulfonyl)ethyl)-N-(5-methyl-1H-pyrazol-3-yl)quinazolin-4-amine

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / tetrahydrofuran

3: hydrogenchloride; potassium tert-butylate / palladium; Pd-C / ethyl acetate; tetrahydrofuran

With hydrogenchloride; potassium tert-butylate; Pd-C; palladium; In tetrahydrofuran; ethyl acetate;

Reference yield:

: 352-13-6
4-flourophenylmagnesium bromide

: 1241916-14-2
2-(1-(4-fluorophenyl)-2-(methylsulfonyl)ethyl)-N-(5-methyl-1H-pyrazol-3-yl)quinazolin-4-amine

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / tetrahydrofuran

2: DIEA / N,N-dimethyl-formamide; water

3: hydrogenchloride; potassium tert-butylate / palladium; Pd-C / ethyl acetate; tetrahydrofuran

With hydrogenchloride; DIEA; potassium tert-butylate; Pd-C; palladium; In tetrahydrofuran; water; ethyl acetate; N,N-dimethyl-formamide;