Benzenemethanol, alpha-[(1R)-1-aminopropyl]-4-methoxy-, (alphaS)-rel- (9CI)

Base Information

Chemical Name:Benzenemethanol, alpha-[(1R)-1-aminopropyl]-4-methoxy-, (alphaS)-rel- (9CI)
CAS No.:792900-49-3
Molecular Formula:C₁₁H₁₇NO₂
Molecular Weight:195.261
Hs Code.:
Mol file:792900-49-3.mol

Synonyms:Benzenemethanol, alpha-[(1R)-1-aminopropyl]-4-methoxy-, (alphaS)-rel- (9CI)

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Benzenemethanol, alpha-[(1R)-1-aminopropyl]-4-methoxy-, (alphaS)-rel- (9CI)

Chemical Property:

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Technology Process of Benzenemethanol, alpha-[(1R)-1-aminopropyl]-4-methoxy-, (alphaS)-rel- (9CI)

There total 10 articles about Benzenemethanol, alpha-[(1R)-1-aminopropyl]-4-methoxy-, (alphaS)-rel- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.4%

: (1S*,2S*)-1-(4-methoxyphenyl)-2-nitrobutan-1-ol

: 792900-49-3
(1S*,2S*)-2-amino-1-(4-methoxyphenyl)butan-1-ol

Guidance literature:: With palladium on activated charcoal; hydrogen; In ethanol; at 20 ℃; for 18h; Sealed tube;

Reference yield:

: (1R,2S)-(-)-2-Amino-1-(4-methoxyphenyl)-1-<(tert-butyldimethylsilyl)oxy>-butane

: 792900-49-3
(1R,2R)-2-Amino-1-(4-methoxyphenyl)-1-butanol

: (1R,2S)-(-)-2-Amino-1-(4-methoxyphenyl)-1-butanol

Guidance literature:: With hydrogen fluoride; In acetonitrile; at 50 ℃; for 17h; Title compound not separated from byproducts;
DOI:10.1016/S0040-4020(01)81972-4

Reference yield:

: 123-11-5
4-methoxy-benzaldehyde

: 792900-49-3
(+/-)-(1R,2S)-2-amino-1-(4-methoxyphenyl)-1-butanol

Guidance literature:: Multi-step reaction with 3 steps

1: n-BuLi / tetrahydrofuran / 0.25 h / -78 °C

2: 57 percent / NaH / tetrahydrofuran

3: aq. LiOH / ethanol / 20 h / Heating

With lithium hydroxide; n-butyllithium; sodium hydride; In tetrahydrofuran; ethanol;
DOI:10.1021/jo0161734