(S)-2-cyclopropyl-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N,2-dimethyl-3-phenylpropanamide

Base Information

Chemical Name:(S)-2-cyclopropyl-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N,2-dimethyl-3-phenylpropanamide
CAS No.:1068602-45-8
Molecular Formula:C₂₃H₂₉NO₂
Molecular Weight:351.489
Hs Code.:

Synonyms:(S)-2-cyclopropyl-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N,2-dimethyl-3-phenylpropanamide

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Chemical Property of (S)-2-cyclopropyl-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N,2-dimethyl-3-phenylpropanamide

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Technology Process of (S)-2-cyclopropyl-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N,2-dimethyl-3-phenylpropanamide

There total 1 articles about (S)-2-cyclopropyl-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N,2-dimethyl-3-phenylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1068601-84-2
2-cyclopropyl-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methylacrylamide

: 591-51-5
phenyllithium

: 74-88-4
methyl iodide

: 1068602-45-8
(S)-2-cyclopropyl-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N,2-dimethyl-3-phenylpropanamide

Guidance literature:: 2-cyclopropyl-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methylacrylamide; phenyllithium; With lithium chloride; In tetrahydrofuran; dibutyl ether; at -78 - 0 ℃; Inert atmosphere;

methyl iodide; In tetrahydrofuran; dibutyl ether; at 0 ℃; for 2h; optical yield given as %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/ja806021y

Reference yield: 99.0%

: 1068602-45-8
(S)-2-cyclopropyl-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N,2-dimethyl-3-phenylpropanamide

: 1068602-65-2
(2S)-2-cyclopropyl-2-methyl-3-phenylpropanoic acid

Guidance literature:: With tetra(n-butyl)ammonium hydroxide; water; In 1,4-dioxane; at 115 ℃; for 24h; Inert atmosphere;
DOI:10.1021/ja806021y

Reference yield: 93.0%

: 1068602-45-8
(S)-2-cyclopropyl-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N,2-dimethyl-3-phenylpropanamide

: 1068602-68-5
(2S)-2-cyclopropyl-2-methyl-3-phenylpropan-1-ol

Guidance literature:: With n-butyllithium; borane-ammonia complex; diisopropylamine; In tetrahydrofuran; hexane; at 66 ℃; for 24h; Inert atmosphere;
DOI:10.1021/ja806021y