3'-chloro-N-{[(3R)-1-cyclopropylcarbonyl-3-pyrrolidinyl]methyl}-4'-fluoro-N-(1-methylethyl)-4-biphenylcarboxamide

Base Information

Chemical Name:3'-chloro-N-{[(3R)-1-cyclopropylcarbonyl-3-pyrrolidinyl]methyl}-4'-fluoro-N-(1-methylethyl)-4-biphenylcarboxamide
CAS No.:1426095-34-2
Molecular Formula:C₂₅H₂₈ClFN₂O₂
Molecular Weight:442.961
Hs Code.:

Synonyms:3'-chloro-N-{[(3R)-1-cyclopropylcarbonyl-3-pyrrolidinyl]methyl}-4'-fluoro-N-(1-methylethyl)-4-biphenylcarboxamide

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Chemical Property of 3'-chloro-N-{[(3R)-1-cyclopropylcarbonyl-3-pyrrolidinyl]methyl}-4'-fluoro-N-(1-methylethyl)-4-biphenylcarboxamide

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Technology Process of 3'-chloro-N-{[(3R)-1-cyclopropylcarbonyl-3-pyrrolidinyl]methyl}-4'-fluoro-N-(1-methylethyl)-4-biphenylcarboxamide

There total 8 articles about 3'-chloro-N-{[(3R)-1-cyclopropylcarbonyl-3-pyrrolidinyl]methyl}-4'-fluoro-N-(1-methylethyl)-4-biphenylcarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1426095-96-6
4-bromo-N-{[(3R)-1-cyclopropylcarbonyl-3-pyrrolidinyl]methyl}-N-(1-methylethyl)benzamide

: 144432-85-9
3-chloro-4-fluorophenylboronic acid

: 1426095-34-2
3'-chloro-N-{[(3R)-1-cyclopropylcarbonyl-3-pyrrolidinyl]methyl}-4'-fluoro-N-(1-methylethyl)-4-biphenylcarboxamide

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; In 1,4-dioxane; water; at 80 ℃; Inert atmosphere;

Reference yield:

: 199175-10-5
1,1-dimethylethyl (3S)-3-(aminomethyl)-1-pyrrolidinecarboxylate

: 1426095-34-2
3'-chloro-N-{[(3R)-1-cyclopropylcarbonyl-3-pyrrolidinyl]methyl}-4'-fluoro-N-(1-methylethyl)-4-biphenylcarboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane / 4 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

3.1: hydrogenchloride / methanol / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 20 °C

4.2: 20 °C

5.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / 1,4-dioxane; water / 80 °C / Inert atmosphere

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium tris(acetoxy)borohydride; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; dichloromethane; water;

Reference yield:

: 586-76-5
4-Bromobenzoic acid

: 1426095-34-2
3'-chloro-N-{[(3R)-1-cyclopropylcarbonyl-3-pyrrolidinyl]methyl}-4'-fluoro-N-(1-methylethyl)-4-biphenylcarboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 25 °C

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

3.1: hydrogenchloride / methanol / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 20 °C

4.2: 20 °C

5.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / 1,4-dioxane; water / 80 °C / Inert atmosphere

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; oxalyl dichloride; potassium carbonate; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In 1,4-dioxane; methanol; dichloromethane; water;