(3-(6-bromoquinazolin-2-ylamino)-5-(1-methyl-1H-pyrazol-4-yl)phenyl)methanol

Base Information

Chemical Name:(3-(6-bromoquinazolin-2-ylamino)-5-(1-methyl-1H-pyrazol-4-yl)phenyl)methanol
CAS No.:1202036-27-8
Molecular Formula:C₁₉H₁₆BrN₅O
Molecular Weight:410.273
Hs Code.:

Synonyms:(3-(6-bromoquinazolin-2-ylamino)-5-(1-methyl-1H-pyrazol-4-yl)phenyl)methanol

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Chemical Property of (3-(6-bromoquinazolin-2-ylamino)-5-(1-methyl-1H-pyrazol-4-yl)phenyl)methanol

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Technology Process of (3-(6-bromoquinazolin-2-ylamino)-5-(1-methyl-1H-pyrazol-4-yl)phenyl)methanol

There total 4 articles about (3-(6-bromoquinazolin-2-ylamino)-5-(1-methyl-1H-pyrazol-4-yl)phenyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6307-83-1
3-bromo-5-nitro-benzoic acid

: 1202036-27-8
(3-(6-bromoquinazolin-2-ylamino)-5-(1-methyl-1H-pyrazol-4-yl)phenyl)methanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: borane-THF / tetrahydrofuran / 0 - 20 °C

1.2: 0 °C

2.1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / tetrahydrofuran; water / 16 h / 90 °C

3.1: hydrogen / Raney Ni / methanol / 5 h / Inert atmosphere of nitrogen

4.1: isopropyl alcohol / 110 °C

With borane-THF; hydrogen; sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; methanol; water; isopropyl alcohol;

Reference yield:

: 882672-05-1
6-bromo-2-chloroquinazoline

: 1202036-26-7
(3-amino-5-(1-methyl-1H-pyrazol-4-yl)phenyl)methanol

: 1202036-27-8
(3-(6-bromoquinazolin-2-ylamino)-5-(1-methyl-1H-pyrazol-4-yl)phenyl)methanol

Guidance literature:: In isopropyl alcohol; at 110 ℃;

Reference yield:

: 1202036-25-6
(3-(1-methyl-1H-pyrazol-4-yl)-5-nitrophenyl)methanol

: 1202036-27-8
(3-(6-bromoquinazolin-2-ylamino)-5-(1-methyl-1H-pyrazol-4-yl)phenyl)methanol

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / Raney Ni / methanol / 5 h / Inert atmosphere of nitrogen

2: isopropyl alcohol / 110 °C

With hydrogen; Raney Ni; In methanol; isopropyl alcohol;