6-(4-chlorophenyl)-3-(4-(2-hydroxy-2-methylpropoxy)-3-methoxyphenyl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one

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Chemical Name:6-(4-chlorophenyl)-3-(4-(2-hydroxy-2-methylpropoxy)-3-methoxyphenyl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one
CAS No.:1221419-37-9
Molecular Formula:C₂₃H₂₂ClN₃O₄
Molecular Weight:439.898
Hs Code.:

Synonyms:6-(4-chlorophenyl)-3-(4-(2-hydroxy-2-methylpropoxy)-3-methoxyphenyl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one

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Chemical Property of 6-(4-chlorophenyl)-3-(4-(2-hydroxy-2-methylpropoxy)-3-methoxyphenyl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one

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Technology Process of 6-(4-chlorophenyl)-3-(4-(2-hydroxy-2-methylpropoxy)-3-methoxyphenyl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one

There total 4 articles about 6-(4-chlorophenyl)-3-(4-(2-hydroxy-2-methylpropoxy)-3-methoxyphenyl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.0%

: 1221420-15-0
6-bromo-3-(4-(2-hydroxy-2-methylpropoxy)-3-methoxyphenyl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one

: 1679-18-1
4-Chlorophenylboronic acid

: 1221419-37-9
6-(4-chlorophenyl)-3-(4-(2-hydroxy-2-methylpropoxy)-3-methoxyphenyl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetra(n-butyl)ammonium hydroxide; potassium carbonate; In water; toluene; at 90 ℃;
DOI:10.1016/j.bmcl.2015.09.018

Reference yield:

: (Z)-methyl 4-bromo-1-(((dimethylamino)methylene)amino)-1H-pyrrole-2-carboxylate

: 1221419-37-9
6-(4-chlorophenyl)-3-(4-(2-hydroxy-2-methylpropoxy)-3-methoxyphenyl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid / acetonitrile / 0.5 h / 160 °C / Microwave irradiation

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; tetra(n-butyl)ammonium hydroxide / toluene; water / 90 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetra(n-butyl)ammonium hydroxide; potassium carbonate; acetic acid; In water; toluene; acetonitrile; 2: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.bmcl.2015.09.018

Reference yield:

: C₈H₁₀BrN₃O₂

: 1221419-37-9
6-(4-chlorophenyl)-3-(4-(2-hydroxy-2-methylpropoxy)-3-methoxyphenyl)pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.25 h / 20 °C

2: acetic acid / acetonitrile / 1 h / 160 °C / Microwave irradiation

3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; tetra(n-butyl)ammonium hydroxide / toluene; water / 90 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetra(n-butyl)ammonium hydroxide; potassium carbonate; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In water; N,N-dimethyl-formamide; toluene; acetonitrile; 3: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.bmcl.2015.09.018