Technology Process of C25H24N2O5
There total 3 articles about C25H24N2O5 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(R)-4-benzyl-3-(prop-2-enoyl)-1,3-oxazolidin-2-one;
With
copper(II) bis(trifluoromethanesulfonate); 2,2-bis[(4S)-4-isopropyloxazolin-2-yl]propane;
In
dichloromethane;
at 20 ℃;
for 0.5h;
Inert atmosphere;
Molecular sieve;
(R)-4-benzyl-3-(prop-2-enoyl)-1,3-oxazolidin-2-one;
In
dichloromethane;
at 0 ℃;
for 24h;
optical yield given as %de;
enantioselective reaction;
Inert atmosphere;
Molecular sieve;
DOI:10.1016/j.tet.2011.12.041
- Guidance literature:
-
(R)-4-benzyl-3-(prop-2-enoyl)-1,3-oxazolidin-2-one;
With
titanium(IV) dichlorodiisopropylate;
In
dichloromethane;
at 20 ℃;
for 0.5h;
Inert atmosphere;
Molecular sieve;
1-(phenoxycarbonyl)-1,2-dihydropyridine;
In
dichloromethane;
at 0 ℃;
for 24h;
diastereoselective reaction;
Inert atmosphere;
DOI:10.1016/j.tet.2011.12.041
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium tetrahydroborate / ethanol / -78 °C
1.2: 24 h / -78 °C
2.1: titanium(IV) dichlorodiisopropylate / dichloromethane / 0.5 h / 20 °C / Inert atmosphere; Molecular sieve
2.2: 24 h / 0 °C / Inert atmosphere
With
sodium tetrahydroborate; titanium(IV) dichlorodiisopropylate;
In
ethanol; dichloromethane;
2.2: Diels-Alder reaction;
DOI:10.1016/j.tet.2011.12.041
