1-(tert-butoxycarbonyl)-4-(1-hydroxycyclohexyl)-2,6-diphenyl-1,4-dihydropyridine

Base Information

Chemical Name:1-(tert-butoxycarbonyl)-4-(1-hydroxycyclohexyl)-2,6-diphenyl-1,4-dihydropyridine
CAS No.:908255-06-1
Molecular Formula:C₂₈H₃₃NO₃
Molecular Weight:431.575
Hs Code.:

Synonyms:1-(tert-butoxycarbonyl)-4-(1-hydroxycyclohexyl)-2,6-diphenyl-1,4-dihydropyridine

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Chemical Property of 1-(tert-butoxycarbonyl)-4-(1-hydroxycyclohexyl)-2,6-diphenyl-1,4-dihydropyridine

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Technology Process of 1-(tert-butoxycarbonyl)-4-(1-hydroxycyclohexyl)-2,6-diphenyl-1,4-dihydropyridine

There total 3 articles about 1-(tert-butoxycarbonyl)-4-(1-hydroxycyclohexyl)-2,6-diphenyl-1,4-dihydropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 854280-12-9
1-(tert-butoxycarbonyl)-2,6-diphenyl-1,4-dihydropyridine

: 108-94-1,11119-77-0,9003-41-2,9075-99-4
cyclohexanone

: 908255-06-1
1-(tert-butoxycarbonyl)-4-(1-hydroxycyclohexyl)-2,6-diphenyl-1,4-dihydropyridine

Guidance literature:: 1-(tert-butoxycarbonyl)-2,6-diphenyl-1,4-dihydropyridine; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.0833333h;

cyclohexanone; In tetrahydrofuran; hexane; at -78 ℃; for 2h;
DOI:10.1021/jo0607360

Reference yield:

: 854280-05-0
tert-butyl 2,6-dioxopiperidine-1-carboxylate

: 908255-06-1
1-(tert-butoxycarbonyl)-4-(1-hydroxycyclohexyl)-2,6-diphenyl-1,4-dihydropyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium diisopropylamide / tetrahydrofuran; hexane / 2 h / -78 °C

1.2: 64 percent / tetrahydrofuran; hexane / 15 h / -78 - 20 °C

2.1: 88 percent / Na₂CO₃ / PdCl₂(PPh₃)2 / tetrahydrofuran; H₂O; ethanol / 0.5 h / Heating

3.1: n-BuLi / tetrahydrofuran; hexane / 0.08 h / -78 °C

3.2: 80 percent / tetrahydrofuran; hexane / 2 h / -78 °C

With n-butyllithium; sodium carbonate; lithium diisopropyl amide; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; ethanol; hexane; water; 2.1: Suzuki-Miyaura coupling;
DOI:10.1021/jo0607360

Reference yield:

: 854280-07-2
2,6-bis[di(phenyloxy)phosphoryloxy]-1-(tert-butoxycarbonyl)-1,4-dihydropyridine

: 908255-06-1
1-(tert-butoxycarbonyl)-4-(1-hydroxycyclohexyl)-2,6-diphenyl-1,4-dihydropyridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: 88 percent / Na₂CO₃ / PdCl₂(PPh₃)2 / tetrahydrofuran; H₂O; ethanol / 0.5 h / Heating

2.1: n-BuLi / tetrahydrofuran; hexane / 0.08 h / -78 °C

2.2: 80 percent / tetrahydrofuran; hexane / 2 h / -78 °C

With n-butyllithium; sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; ethanol; hexane; water; 1.1: Suzuki-Miyaura coupling;
DOI:10.1021/jo0607360