854280-07-2

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 854280-05-0 tert-butyl 2,6-dioxopiperidine-1-carboxylate 
• 2524-64-3 chlorophosphoric acid diphenyl ester 
• 1121-89-7 piperidine-2,6-dione 

Downstream Products

• 3558-69-8 2,6-diphenylpyridine 
• 908255-06-1 1-(tert-butoxycarbonyl)-4-(1-hydroxycyclohexyl)-2,6-diphenyl-1,4-dihydropyridine 
• 908255-11-8 1-(tert-butoxycarbonyl)-4,4-diallyl-2,6-diphenyl-1,4-dihydropyridine 

Relevant academic research and scientific papers

Asymmetric cycloetherification of in situ generated cyanohydrins through the concomitant construction of three chiral carbon centers

The organocatalytic enantio- A nd diastereoselective cycloetherification of in situ generated cyanohydrins through the concomitant construction of three chiral carbon centers is reported. This protocol facilitates the concise synthesis of optically active

Synthesis and reactivity of imide-derived bisvinyl phosphates. Reactivity of 2,6-disubstituted 1,4-dihydropyridines

Symmetrical and unsymmetrical 2,6-disubstituted dihydropyridines were prepared in high yields under mild conditions using the Suzuki and Stille Pd-catalyzed coupling reactions of imide-derived bisvinyl phosphates with a range of aryl, heteroaryl, and alkenyl moieties. The alkylation reaction at C-4 easily afforded original tri- and tetrasubstituted dihydropyridines. Hydrolysis of the latter under acidic condition provided efficiently either open-chain 1,5-diketones or di- or trisubstituted pyridines.

Reactivity of bis-vinylphosphates obtained from imide derivatives. Synthesis of 2,6-disubstituted 1,4-dihydropyridines

The Pd-catalyzed functionalization of lactam-derived vinyl phosphates has become an important tool in the last decade for the synthesis of nitrogen-containing heterocycles. By using this method, we were able to introduce alkenyl, aryl and heteroaryl groups on bis-vinylphosphate derivatives to provide efficient access to 2,6-disubstituted 1,4-dihydropyridines.