2',3'-O-isopropylidene-5'-O-methoxy-methyl-6-phenylthiouridine

Base Information

• Chemical Name: 2',3'-O-isopropylidene-5'-O-methoxy-methyl-6-phenylthiouridine
• CAS No.: 80614-90-0
• Molecular Formula: C₂₀H₂₄N₂O₇S
• Molecular Weight: 436.486
• Mol file: 80614-90-0.mol

Synonyms:2',3'-O-isopropylidene-5'-O-methoxy-methyl-6-phenylthiouridine

Chemical Property of 2',3'-O-isopropylidene-5'-O-methoxy-methyl-6-phenylthiouridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2',3'-O-isopropylidene-5'-O-methoxy-methyl-6-phenylthiouridine

There total 2 articles about 2',3'-O-isopropylidene-5'-O-methoxy-methyl-6-phenylthiouridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2',3'-O-isopropylidene-5'-O-methoxymethyl-uridine (80614-78-4) + diphenyldisulfane (882-33-7) → 2',3'-O-isopropylidene-5'-O-methoxy-methyl-6-phenylthiouridine (80614-90-0)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; at -70 ℃;

DOI:10.1248/cpb.31.2164

Reference yield:

2',3'-O-isopropylidene-5'-O-methoxymethyl-uridine (80614-78-4) + diphenyldisulfane (882-33-7) → 2',3'-O-isopropylidene-5'-O-methoxy-methyl-6-phenylthiouridine (80614-90-0) + 5,6-diphenylthio-2',3'-O-isopropylidene-5'-O-methoxymethyluridine (85451-46-3)

Guidance literature:

With lithium diisopropyl amide; Yield given. Multistep reaction. Yields of byproduct given; 1.) THF, -70 deg C, 1h; 2.) -70 deg C, 2h;

DOI:10.1016/0040-4020(82)80016-1

Reference yield: 85.5%

2',3'-O-isopropylidene-5'-O-methoxy-methyl-6-phenylthiouridine (80614-90-0) → 6-phenylthiouridine (85451-50-9)

Guidance literature:

With trifluoroacetic acid; for 48h; Ambient temperature;

DOI:10.1248/cpb.31.1222

upstream raw materials:

2',3'-O-isopropylidene-5'-O-methoxymethyl-uridine

diphenyldisulfane

Downstream raw materials:

2',3'-O-isopropylidene-5'-O-methoxymethyl-5-trimethylsilyl-6-phenylthiouridine

5-butyl-2',3'-O-isopropylidene-5'-O-methoxymethyl-6-phenylthiouridine

5-ethoxycarbonyl-2',3'-O-isopropylidene-5'-O-methoxymethyl-6-phenylthiouridine

6-phenylthiouridine