10,11-dihydro-10-(4-iodobenzoyl)-5H-pyrrolo[2,1-c][1,4]benzodiazepine

Base Information

• Chemical Name: 10,11-dihydro-10-(4-iodobenzoyl)-5H-pyrrolo[2,1-c][1,4]benzodiazepine
• CAS No.: 179408-46-9
• Molecular Formula: C₁₉H₁₅IN₂O
• Molecular Weight: 414.245
• Mol file: 179408-46-9.mol

Synonyms:10,11-dihydro-10-(4-iodobenzoyl)-5H-pyrrolo[2,1-c][1,4]benzodiazepine

Chemical Property of 10,11-dihydro-10-(4-iodobenzoyl)-5H-pyrrolo[2,1-c][1,4]benzodiazepine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 10,11-dihydro-10-(4-iodobenzoyl)-5H-pyrrolo[2,1-c][1,4]benzodiazepine

There total 1 articles about 10,11-dihydro-10-(4-iodobenzoyl)-5H-pyrrolo[2,1-c][1,4]benzodiazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a][1,4]diazepine (22162-53-4) + 4-iodobenzoic acid chloride (1711-02-0) → 10,11-dihydro-10-(4-iodobenzoyl)-5H-pyrrolo[2,1-c][1,4]benzodiazepine (179408-46-9)

Guidance literature:

With triethylamine; In dichloromethane;

DOI:10.1016/j.bmcl.2005.08.007

Reference yield:

10,11-dihydro-10-(4-iodobenzoyl)-5H-pyrrolo[2,1-c][1,4]benzodiazepine (179408-46-9) + 2-(tri-n-butylstannyl)thiazole (121359-48-6) → 10,11-dihydro-10-[4-(2-thiazolyl)benzoyl]-5H-pyrrolo[2,1-c][1,4]benzodiazepine

Guidance literature:

tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene;

Reference yield:

10,11-dihydro-10-(4-iodobenzoyl)-5H-pyrrolo[2,1-c][1,4]benzodiazepine (179408-46-9) + 2-tri-n-butylstannylpyridine (17997-47-6) → 10,11-dihydro-10-[4-(2-pyridinyl)benzoyl]-5H-pyrrolo[2,1-c][1,4]benzodiazepine

Guidance literature:

tetrakis(triphenylphosphine) palladium⁽⁰⁾; In chloroform; toluene;

upstream raw materials:

10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a][1,4]diazepine

4-iodobenzoic acid chloride

Downstream raw materials:

(4-Thiophen-2-yl-phenyl)-(5H-10,11-dihydro-pyrrolo[2,1-c][1,4]benzodiazepin-10-yl)-methanone