Spiro[4.5]dec-9-en-6-ol, 6,10-dimethyl-2-(1-methylethenyl)-, (2R,5R,6S)- (9CI)

Base Information

Chemical Name:Spiro[4.5]dec-9-en-6-ol, 6,10-dimethyl-2-(1-methylethenyl)-, (2R,5R,6S)- (9CI)
CAS No.:791835-48-8
Molecular Formula:C₁₅H₂₄O
Molecular Weight:220.355
Hs Code.:
Mol file:791835-48-8.mol

Synonyms:Spiro[4.5]dec-9-en-6-ol, 6,10-dimethyl-2-(1-methylethenyl)-, (2R,5R,6S)- (9CI)

Suppliers and Price of Spiro[4.5]dec-9-en-6-ol, 6,10-dimethyl-2-(1-methylethenyl)-, (2R,5R,6S)- (9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 5 raw suppliers

Chemical Property of Spiro[4.5]dec-9-en-6-ol, 6,10-dimethyl-2-(1-methylethenyl)-, (2R,5R,6S)- (9CI)

Chemical Property:

PSA：20.23000
LogP:3.84010

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Spiro[4.5]dec-9-en-6-ol, 6,10-dimethyl-2-(1-methylethenyl)-, (2R,5R,6S)- (9CI)

There total 9 articles about Spiro[4.5]dec-9-en-6-ol, 6,10-dimethyl-2-(1-methylethenyl)-, (2R,5R,6S)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 791835-59-1
Methanesulfonic acid (S)-2-((2R,5R,10S)-10-hydroxy-6,10-dimethyl-spiro[4.5]dec-6-en-2-yl)-propyl ester

: 791835-48-8
(2R,5R,10S)-6,11-spirovetivadien-10-ol

Guidance literature:: With lithium carbonate; lithium bromide; In N,N-dimethyl-formamide; at 140 ℃; for 10h;
DOI:10.1021/jo040189n

Reference yield:

: 17974-84-4
(11S)-3-oxo-eudesma-1,4-dien-13-oic acid

: 791835-48-8
(2R,5R,10S)-6,11-spirovetivadien-10-ol

Guidance literature:: Multi-step reaction with 8 steps

1.1: 5.79 g / H₂SO₄ / 4 h / Heating

2.1: MeLi; CuCN / tetrahydrofuran; hexamethylphosphoric acid triamide; diethyl ether / 0.5 h / 0 °C

2.2: 85 percent / tetrahydrofuran; hexamethylphosphoric acid triamide; diethyl ether / 0.33 h / -23 °C

3.1: 98 percent / BF₃*Et₂O / acetic acid / 7 h / 20 °C

4.1: 59 percent / Ca; liquid NH₃ / diethyl ether / 5 h / Heating

5.1: 91 percent / NaHCO₃; 18-crown-6; oxone / H₂O; acetone; CH₂Cl₂ / 1.5 h / 0 °C

6.1: 64 percent / BF₃*Et₂O / CH₂Cl₂ / 2 h / -40 °C

7.1: pyridine / 0.5 h / 0 °C

8.1: 259 mg / Li₂CO₃; LiBr / dimethylformamide / 10 h / 140 °C

With pyridine; Oxone; 18-crown-6 ether; sulfuric acid; boron trifluoride diethyl etherate; ammonia; methyllithium; lithium carbonate; sodium hydrogencarbonate; calcium; lithium bromide; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; dichloromethane; water; acetic acid; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jo040189n

Reference yield:

: 18172-86-6
methyl (11S)-3-oxo-7αH-eudesma-1,4-dien-12-oate

: 791835-48-8
(2R,5R,10S)-6,11-spirovetivadien-10-ol

Guidance literature:: Multi-step reaction with 7 steps

1.1: MeLi; CuCN / tetrahydrofuran; hexamethylphosphoric acid triamide; diethyl ether / 0.5 h / 0 °C

1.2: 85 percent / tetrahydrofuran; hexamethylphosphoric acid triamide; diethyl ether / 0.33 h / -23 °C

2.1: 98 percent / BF₃*Et₂O / acetic acid / 7 h / 20 °C

3.1: 59 percent / Ca; liquid NH₃ / diethyl ether / 5 h / Heating

4.1: 91 percent / NaHCO₃; 18-crown-6; oxone / H₂O; acetone; CH₂Cl₂ / 1.5 h / 0 °C

5.1: 64 percent / BF₃*Et₂O / CH₂Cl₂ / 2 h / -40 °C

6.1: pyridine / 0.5 h / 0 °C

7.1: 259 mg / Li₂CO₃; LiBr / dimethylformamide / 10 h / 140 °C

With pyridine; Oxone; 18-crown-6 ether; boron trifluoride diethyl etherate; ammonia; methyllithium; lithium carbonate; sodium hydrogencarbonate; calcium; lithium bromide; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; dichloromethane; water; acetic acid; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jo040189n