Technology Process of 4-[4-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)-phenyl]-[2,2']bipyridinyl
There total 1 articles about 4-[4-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)-phenyl]-[2,2']bipyridinyl which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
potassium acetate;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
dimethyl sulfoxide;
under N2 atm. to soln. bpy-Ph-Br, K2CO3, and bis(pinacolato)diboron in DMSO PdCl2(dppf) was added and heated to 105°C for 17 h; react. mixt. was cooled to room temp., water was added, extd. with CH2Cl2, org. phase was evapd. in vacuo, residue was extd. with hexane;
DOI:10.1021/ic0483141
- Guidance literature:
-
With
K2CO3;
tetrakis(triphenylphosphine) palladium(0);
In
N,N-dimethyl-formamide;
under N2 atm. Pd(PPh3)4 was added to mixt. Ru complex, bpy-ph-B(OR)2, K2CO3 and DMF, heated at 120°C for 24 h, solvent was evapd., residue was dissolved in water/acetone (10:1), aq. soln. NH4PF6 was added; acetone was removed in vacuo, ppt. was filtered, washed with water and Et2O, purified on silica column with MeCN/H2O/MeOH/KNO3, 4:1:1:0.1 as eluent + product was purified by preparative tlc (SiO2), recrystn. from acetone/hexane;
DOI:10.1021/ic0483141
