1-(1-adamantyl)methyl-2,4-dioxo-5-(4-methoxyphenyl)methyl-3-phenylhydrazono-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

Base Information

Chemical Name:1-(1-adamantyl)methyl-2,4-dioxo-5-(4-methoxyphenyl)methyl-3-phenylhydrazono-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine
CAS No.:163617-87-6
Molecular Formula:C₃₄H₃₆N₄O₃
Molecular Weight:548.685
Hs Code.:

Synonyms:1-(1-adamantyl)methyl-2,4-dioxo-5-(4-methoxyphenyl)methyl-3-phenylhydrazono-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

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Chemical Property of 1-(1-adamantyl)methyl-2,4-dioxo-5-(4-methoxyphenyl)methyl-3-phenylhydrazono-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

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Technology Process of 1-(1-adamantyl)methyl-2,4-dioxo-5-(4-methoxyphenyl)methyl-3-phenylhydrazono-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

There total 4 articles about 1-(1-adamantyl)methyl-2,4-dioxo-5-(4-methoxyphenyl)methyl-3-phenylhydrazono-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.3%

: 163617-86-5
N-(1-adamantyl)methyl-N'-(4-methoxyphenyl)methyl-1,2-phenylenediamine

: 19288-90-5
2-(phenylhydrazono)-propanedioyl dichloride

: 163617-87-6
1-(1-adamantyl)methyl-2,4-dioxo-5-(4-methoxyphenyl)methyl-3-phenylhydrazono-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

Guidance literature:: In ethyl acetate; for 2h; Reflux;
DOI:10.1016/j.bmc.2011.05.057

Reference yield:

: 163617-85-4
N-(1-adamantanecarbonyl)-N'-(4-methoxyphenyl)methyl-1,2-phenylenediamine

: 163617-87-6
1-(1-adamantyl)methyl-2,4-dioxo-5-(4-methoxyphenyl)methyl-3-phenylhydrazono-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

Guidance literature:: Multi-step reaction with 2 steps

1.1: dimethylsulfide borane complex / tetrahydrofuran / 1.25 h / 10 - 110 °C / Inert atmosphere

1.2: 3 h / Reflux

2.1: ethyl acetate / 2 h / Reflux

With dimethylsulfide borane complex; In tetrahydrofuran; ethyl acetate;
DOI:10.1016/j.bmc.2011.05.057

Reference yield:

: 5729-16-8
N-(4-methoxy-benzyl)-benzene-1,2-diamine

: 163617-87-6
1-(1-adamantyl)methyl-2,4-dioxo-5-(4-methoxyphenyl)methyl-3-phenylhydrazono-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / tetrahydrofuran / 1.5 h / 60 °C

2.1: dimethylsulfide borane complex / tetrahydrofuran / 1.25 h / 10 - 110 °C / Inert atmosphere

2.2: 3 h / Reflux

3.1: ethyl acetate / 2 h / Reflux

With dimethylsulfide borane complex; triethylamine; In tetrahydrofuran; ethyl acetate;
DOI:10.1016/j.bmc.2011.05.057