19288-90-5

Basic information

• Product Name: 2-(2-phenylhydrazono)Malonyl dichloride
• Synonyms: 2-(2-phenylhydrazono)Malonyl dichloride
• CAS NO: 19288-90-5
• Molecular Formula: C₉H₆Cl₂N₂O₂
• Molecular Weight: 245.06214
• Mol File: 19288-90-5.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(2-phenylhydrazono)Malonyl dichloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-phenylhydrazono)Malonyl dichloride(19288-90-5)
• EPA Substance Registry System: 2-(2-phenylhydrazono)Malonyl dichloride(19288-90-5)

Safety Data

• Hazardous Substances Data: 19288-90-5(Hazardous Substances Data)

Usage

Type of compound

Dichloride derivative of malonyl hydrazide

State at room temperature

Solid

Use in organic synthesis

Versatile building block for the preparation of various organic compounds

Reactivity

Can form hydrazones, valuable in the development of new organic molecules

Applications

Pharmaceuticals, agrochemicals, and materials science

Potential properties

Antiviral and antimicrobial, of interest for medicinal chemistry research.

Upstream product

• 40885-82-3 2-(phenylhydrazono)malonic acid 
• 10026-13-8 phosphorus pentachloride 
• 100-63-0 phenylhydrazine 
• 6134-59-4 diethyl 2-(phenylhydrazono)malonate 
• 142-04-1 aniline hydrochloride 

Downstream Products

• 161455-86-3 1-(4-Methoxy-benzyl)-5-phenyl-3-(phenyl-hydrazono)-1,5-dihydro-benzo[b][1,4]diazepine-2,4-dione 
• 151385-79-4 1-(3-Methyl-butyl)-5-phenyl-3-(phenyl-hydrazono)-1,5-dihydro-benzo[b][1,4]diazepine-2,4-dione 
• 151385-90-9 7-Fluoro-5-(3-methyl-butyl)-1-phenyl-3-(phenyl-hydrazono)-1,5-dihydro-benzo[b][1,4]diazepine-2,4-dione 
• 151385-65-8 2,4-dioxo-5-N-(2-fluorophenyl)-1-N-(3-methylbut-1-yl)-3-phenylhydrazono-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine 
• 875552-57-1 2-[2,4-dioxo-5-phenyl-3-(phenylhydrazono)-2,3,4,5-tetrahydrobenzo[b][1,4]diazepin-1-yl]-N-(4-methoxyphenyl)-N-methylacetamide 
• 161455-94-3 2-[2,4-dioxo-5-phenyl-3-(phenylhydrazono)-2,3,4,5-tetrahydrobenzo[b][1,4]diazepin-1-yl]-N-isopropyl-N-(4-methoxyphenyl)acetamide 
• 1422260-03-4 (Z)-3-(2-phenylhydrazono)-1-methyl-5-phenyl-1H-benzo[b][1,4]diazepine-2,4(3H,5H)-dione 
• 1422260-04-5 (E)-3-(2-phenylhydrazono)-1-methyl-5-phenyl-1H-benzo[b][1,4]diazepine-2,4(3H,5H)-dione 
• 17762-13-9 methyl 4-hydroxylcinnoline-3-carboxylate 
• 163617-87-6 1-(1-adamantyl)methyl-2,4-dioxo-5-(4-methoxyphenyl)methyl-3-phenylhydrazono-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine 
• 163618-08-4 1-(1-adamantyl)methyl-2,4-dioxo-7-fluoro-5-[2-(morpholin-4-yl)ethyl]-3-phenylhydrazono-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine 
• 163617-97-8 1-(1-adamantyl)methyl-2,4-dioxo-5-[2-(pyrrolidin-1-yl)ethyl]-3-phenylhydrazono-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine 
• 163617-94-5 1-(1-adamantyl)methyl-2,4-dioxo-5-[2-(morpholin-4-yl)ethyl]-3-phenylhydrazono-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine 
• 163617-75-2 2,4-dioxo-5-(4-methoxyphenyl)methyl-1-(3-methyl-1-butyl)-3-phenylhydrazono-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine 

Relevant articles and documents

Synthesis and Structure-Affinity Relationship of Small Molecules for Imaging Human CD80 by Positron Emission Tomography

The costimulatory molecule CD80 is an early marker for immune activation. It is upregulated on activated antigen-presenting cells. We aimed at developing a tracer for imaging CD80 by positron emission tomography (PET). Novel CD80 ligands were synthesized

Novel benzodiazepine photoaffinity probe stereoselectively labels a site deep within the membrane-spanning domain of the cholecystokinin receptor

An understanding of the molecular basis of drug action provides opportunities for refinement of drug properties and for development of more potent and selective molecules that act at the same biological target. In this work, we have identified the active

IMMUNOMODULATING HETEROCYCLIC COMPOUNDS

Compounds of formula (I) are inhibitors of CD80 and useful in immunomodulation therapy: wherein R1 and R3 independently represent H; F; CI; Br; -NO2; -CN; C1-C6 alkyl optionally substituted by F or Cl; or C1-C6 alkoxy optionally substituted by F; R4 represents a carboxylic acid group (-COOH) or an ester thereof, or -C(=O)NR6R7, -NR7C(=O)R6, -NR7C(=O)OR6, -NHC(=O)NR7R6 or -NHC(=S)NR7R6 wherein R6 represents H, or a radical of formula - (Alk)m-Q wherein m is 0 or 1, Alk is an optionally substituted divalent straight or branched C1-C12 alkylene, or C2-C12 alkenylene, or C2-C12 alkynylene radical or a divalent C3-C12 carbocyclic radical, any of which radicals may contain one or more -O-, -S- or -N(R8)- links wherein R8 represents H or C1-C4 alkyl, C3--C4 alkenyl, C3-C4 alkynyl, or C3-C6 cycloalkyl, and Q represents H; -NR9R10 wherein R9 and R10 independently represents H; C1-C4 alkyl; C3-C4 alkenyl; C3-C4 alkynyl; C3-C6 cycloalkyl; an ester group; an optionally substituted carbocyclic or heterocyclic group; or R9 and R10 form a ring when taken together with the nitrogen to which they are attached, which ring is optionally substituted; and R7 represents H or C1-C6 alkyl; or when taken together with the atom or atoms to which they are attached R6 and R7 form an optionally substituted monocyclic heterocyclic ring having 5, 6 or 7 ring atoms; and X represents a bond or a divalent radical of formula - (Z)n-(Alk)- or - (Alk)-(Z)n- -wherein Z represents -O-, -S- or -NH-, Alk is as defined in relation to R6 and n is 0 or 1.