N-(7-(1-((4'-chlorobiphenyl-2-yl)methyl)-3-fluoropiperidin-4-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)-4-((R)-4-morpholino-1-(phenylthio)butan-2-ylamino)-3-(trifluoromethylsulfonyl)benzenesulfonamide

Base Information

Chemical Name:N-(7-(1-((4'-chlorobiphenyl-2-yl)methyl)-3-fluoropiperidin-4-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)-4-((R)-4-morpholino-1-(phenylthio)butan-2-ylamino)-3-(trifluoromethylsulfonyl)benzenesulfonamide
CAS No.:1274803-40-5
Molecular Formula:C₄₆H₅₀ClF₄N₇O₅S₃
Molecular Weight:988.592
Hs Code.:

N-(7-(1-((4'-chlorobiphenyl-2-yl)methyl)-3-fluoropiperidin-4-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)-4-((R)-4-morpholino-1-(phenylthio)butan-2-ylamino)-3-(trifluoromethylsulfonyl)benzenesulfonamide

Synonyms:N-(7-(1-((4'-chlorobiphenyl-2-yl)methyl)-3-fluoropiperidin-4-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)-4-((R)-4-morpholino-1-(phenylthio)butan-2-ylamino)-3-(trifluoromethylsulfonyl)benzenesulfonamide

Suppliers and Price of N-(7-(1-((4'-chlorobiphenyl-2-yl)methyl)-3-fluoropiperidin-4-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)-4-((R)-4-morpholino-1-(phenylthio)butan-2-ylamino)-3-(trifluoromethylsulfonyl)benzenesulfonamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-(7-(1-((4'-chlorobiphenyl-2-yl)methyl)-3-fluoropiperidin-4-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)-4-((R)-4-morpholino-1-(phenylthio)butan-2-ylamino)-3-(trifluoromethylsulfonyl)benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-(7-(1-((4'-chlorobiphenyl-2-yl)methyl)-3-fluoropiperidin-4-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)-4-((R)-4-morpholino-1-(phenylthio)butan-2-ylamino)-3-(trifluoromethylsulfonyl)benzenesulfonamide

There total 14 articles about N-(7-(1-((4'-chlorobiphenyl-2-yl)methyl)-3-fluoropiperidin-4-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)-4-((R)-4-morpholino-1-(phenylthio)butan-2-ylamino)-3-(trifluoromethylsulfonyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 12.0%

: 1274806-00-6
1-((4'-chlorobiphenyl-2-yl)methyl)-3-fluoropiperidin-4-one

: 1274804-70-4
(R)-4-(4-morpholino-1-(phenylthio)butan-2-ylamino)-N-(5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)-3-(trifluoromethylsulfonyl)-benzenesulfonamide

: 1274803-40-5
N-(7-(1-((4'-chlorobiphenyl-2-yl)methyl)-3-fluoropiperidin-4-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)-4-((R)-4-morpholino-1-(phenylthio)butan-2-ylamino)-3-(trifluoromethylsulfonyl)benzenesulfonamide

Guidance literature:: 1-((4'-chlorobiphenyl-2-yl)methyl)-3-fluoropiperidin-4-one; (R)-4-(4-morpholino-1-(phenylthio)butan-2-ylamino)-N-(5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)-3-(trifluoromethylsulfonyl)-benzenesulfonamide; With sodium hydrogencarbonate; In 1,2-dichloro-ethane; at 20 ℃; for 3h;

With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 65 ℃; for 16h;

Reference yield:

: 71233-25-5
ethyl 1-tert-butoxycarbonyl-3-oxopiperidine-4-carboxylate

: 1274803-40-5
N-(7-(1-((4'-chlorobiphenyl-2-yl)methyl)-3-fluoropiperidin-4-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)-4-((R)-4-morpholino-1-(phenylthio)butan-2-ylamino)-3-(trifluoromethylsulfonyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium ethanolate / ethanol / 5 h / 70 °C

2.1: triphenylphosphine / 1,2-dichloro-ethane

2.2: 2.5 h / 70 °C

3.1: DavePhos; caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 0.58 h / 180 °C / Microwave irradiation

4.1: hydrogenchloride / dichloromethane; diethyl ether / 3 h / 0 - 20 °C

5.1: sodium hydrogencarbonate / 1,2-dichloro-ethane / 3 h / 20 °C

5.2: 16 h / 65 °C

With hydrogenchloride; sodium ethanolate; sodium hydrogencarbonate; caesium carbonate; triphenylphosphine; DavePhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; diethyl ether; ethanol; dichloromethane; 1,2-dichloro-ethane;

Reference yield:

: 6630-33-7
ortho-bromobenzaldehyde

: 1274803-40-5
N-(7-(1-((4'-chlorobiphenyl-2-yl)methyl)-3-fluoropiperidin-4-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)-4-((R)-4-morpholino-1-(phenylthio)butan-2-ylamino)-3-(trifluoromethylsulfonyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; ethanol; water / 20 h / 75 °C / Inert atmosphere

2.1: sodium tetrahydroborate; methanol / dichloromethane / 16 h / 0 - 20 °C

3.1: 1H-imidazole; triphenylphosphine; iodine / dichloromethane / 16 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 20 °C

5.1: sodium hydrogencarbonate / 1,2-dichloro-ethane / 3 h / 20 °C

5.2: 16 h / 65 °C

With 1H-imidazole; methanol; sodium tetrahydroborate; iodine; sodium hydrogencarbonate; potassium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; ethanol; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;