(R)-4-(4-morpholino-1-(phenylthio)butan-2-ylamino)-N-(5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)-3-(trifluoromethylsulfonyl)-benzenesulfonamide

Base Information

Chemical Name:(R)-4-(4-morpholino-1-(phenylthio)butan-2-ylamino)-N-(5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)-3-(trifluoromethylsulfonyl)-benzenesulfonamide
CAS No.:1274804-70-4
Molecular Formula:C₂₈H₃₃F₃N₆O₅S₃
Molecular Weight:686.8
Hs Code.:

(R)-4-(4-morpholino-1-(phenylthio)butan-2-ylamino)-N-(5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)-3-(trifluoromethylsulfonyl)-benzenesulfonamide

Synonyms:(R)-4-(4-morpholino-1-(phenylthio)butan-2-ylamino)-N-(5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)-3-(trifluoromethylsulfonyl)-benzenesulfonamide

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Chemical Property of (R)-4-(4-morpholino-1-(phenylthio)butan-2-ylamino)-N-(5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)-3-(trifluoromethylsulfonyl)-benzenesulfonamide

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Technology Process of (R)-4-(4-morpholino-1-(phenylthio)butan-2-ylamino)-N-(5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)-3-(trifluoromethylsulfonyl)-benzenesulfonamide

There total 5 articles about (R)-4-(4-morpholino-1-(phenylthio)butan-2-ylamino)-N-(5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)-3-(trifluoromethylsulfonyl)-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1274804-52-2
4-{4-[4-((R)-3-morpholin-4-yl-1-phenylsulfanylmethyl-propylamino)-3-trifluoromethanesulfonyl-benzenesulfonylamino]-5,8-dihydro-6H-pyrido[3,4d]pyrimidin-7-yl}-piperidine-1-carboxylic acid tert-butyl ester

: 1274804-70-4
(R)-4-(4-morpholino-1-(phenylthio)butan-2-ylamino)-N-(5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)-3-(trifluoromethylsulfonyl)-benzenesulfonamide

Guidance literature:: 4-{4-[4-((R)-3-morpholin-4-yl-1-phenylsulfanylmethyl-propylamino)-3-trifluoromethanesulfonyl-benzenesulfonylamino]-5,8-dihydro-6H-pyrido[3,4d]pyrimidin-7-yl}-piperidine-1-carboxylic acid tert-butyl ester; With hydrogenchloride; In diethyl ether; dichloromethane; at 0 - 20 ℃; for 3h;

With sodium hydrogencarbonate; In dichloromethane; water;

Reference yield:

: 71233-25-5
ethyl 1-tert-butoxycarbonyl-3-oxopiperidine-4-carboxylate

: 1274804-70-4
(R)-4-(4-morpholino-1-(phenylthio)butan-2-ylamino)-N-(5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)-3-(trifluoromethylsulfonyl)-benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium ethanolate / ethanol / 5 h / 70 °C

2.1: triphenylphosphine / 1,2-dichloro-ethane

2.2: 2.5 h / 70 °C

3.1: DavePhos; caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 0.58 h / 180 °C / Microwave irradiation

4.1: hydrogenchloride / dichloromethane; diethyl ether / 3 h / 0 - 20 °C

With hydrogenchloride; sodium ethanolate; caesium carbonate; triphenylphosphine; DavePhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; diethyl ether; ethanol; dichloromethane; 1,2-dichloro-ethane;

Reference yield:

: 39514-19-7
ethyl 1-benzyl-3-oxo-4-piperidinecarboxylate

: 1274804-70-4
(R)-4-(4-morpholino-1-(phenylthio)butan-2-ylamino)-N-(5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)-3-(trifluoromethylsulfonyl)-benzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen / palladium 10% on activated carbon / ethanol / 16 h

1.2: 16 h / 20 °C

2.1: sodium ethanolate / ethanol / 5 h / 70 °C

3.1: triphenylphosphine / 1,2-dichloro-ethane

3.2: 2.5 h / 70 °C

4.1: DavePhos; caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 0.58 h / 180 °C / Microwave irradiation

5.1: hydrogenchloride / dichloromethane; diethyl ether / 3 h / 0 - 20 °C

With hydrogenchloride; hydrogen; sodium ethanolate; caesium carbonate; triphenylphosphine; DavePhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; In 1,4-dioxane; diethyl ether; ethanol; dichloromethane; 1,2-dichloro-ethane;