3-((S)-1-cyclohexyl-3-(methylamino)propan-2-yl)-1-(2-((S)-6-fluoro-1-(4-methoxybutyl)-3-oxoisoindolin-1-yl)ethyl)-1-methylurea

Base Information

Chemical Name:3-((S)-1-cyclohexyl-3-(methylamino)propan-2-yl)-1-(2-((S)-6-fluoro-1-(4-methoxybutyl)-3-oxoisoindolin-1-yl)ethyl)-1-methylurea
CAS No.:1093868-46-2
Molecular Formula:C₂₇H₄₃FN₄O₃
Molecular Weight:490.662
Hs Code.:

Synonyms:3-((S)-1-cyclohexyl-3-(methylamino)propan-2-yl)-1-(2-((S)-6-fluoro-1-(4-methoxybutyl)-3-oxoisoindolin-1-yl)ethyl)-1-methylurea

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Chemical Property of 3-((S)-1-cyclohexyl-3-(methylamino)propan-2-yl)-1-(2-((S)-6-fluoro-1-(4-methoxybutyl)-3-oxoisoindolin-1-yl)ethyl)-1-methylurea

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Technology Process of 3-((S)-1-cyclohexyl-3-(methylamino)propan-2-yl)-1-(2-((S)-6-fluoro-1-(4-methoxybutyl)-3-oxoisoindolin-1-yl)ethyl)-1-methylurea

There total 9 articles about 3-((S)-1-cyclohexyl-3-(methylamino)propan-2-yl)-1-(2-((S)-6-fluoro-1-(4-methoxybutyl)-3-oxoisoindolin-1-yl)ethyl)-1-methylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1093869-25-0
C₃₂H₅₁FN₄O₅

: 1093868-46-2
3-((S)-1-cyclohexyl-3-(methylamino)propan-2-yl)-1-(2-((S)-6-fluoro-1-(4-methoxybutyl)-3-oxoisoindolin-1-yl)ethyl)-1-methylurea

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 2h;

Reference yield:

: 1006-41-3
2-bromo-4-fluorobenzoic acid

: 1093868-46-2
3-((S)-1-cyclohexyl-3-(methylamino)propan-2-yl)-1-(2-((S)-6-fluoro-1-(4-methoxybutyl)-3-oxoisoindolin-1-yl)ethyl)-1-methylurea

Guidance literature:: Multi-step reaction with 7 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 20 °C

2.1: dichloromethane / 4 h / 20 °C

2.2: 1.5 h / 0 - 20 °C

3.1: tert.-butyl lithium / tetrahydrofuran; pentane / 0.5 h / -78 °C

3.2: 4 h / -20 - 0 °C

4.1: titanium ethoxide / 1,4-dioxane / 72 h / 90 °C / sealed tube

5.1: tetrahydrofuran; toluene / 4 h / 100 °C

5.2: 6 h / 100 °C / sealed tube

6.1: sodium hydrogencarbonate / acetonitrile / 4 h

6.2: 1 h

7.1: trifluoroacetic acid / dichloromethane / 2 h

With oxalyl dichloride; tert.-butyl lithium; sodium hydrogencarbonate; trifluoroacetic acid; N,N-dimethyl-formamide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; toluene; acetonitrile; pentane;

Reference yield:

: 17913-18-7
4-(methoxy)-1-chlorobutane

: 1093868-46-2
3-((S)-1-cyclohexyl-3-(methylamino)propan-2-yl)-1-(2-((S)-6-fluoro-1-(4-methoxybutyl)-3-oxoisoindolin-1-yl)ethyl)-1-methylurea

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrahydrofuran / 4 h / Heating / reflux

2.1: tetrahydrofuran; toluene / 4 h / 100 °C

2.2: 6 h / 100 °C / sealed tube

3.1: sodium hydrogencarbonate / acetonitrile / 4 h

3.2: 1 h

4.1: trifluoroacetic acid / dichloromethane / 2 h

With sodium hydrogencarbonate; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; toluene; acetonitrile;