2-(2-bromo-4-fluorophenyl)-4,4-dimethyl-2-oxazoline

Base Information

Chemical Name:2-(2-bromo-4-fluorophenyl)-4,4-dimethyl-2-oxazoline
CAS No.:1093868-91-7
Molecular Formula:C₁₁H₁₁BrFNO
Molecular Weight:272.117
Hs Code.:

Synonyms:2-(2-bromo-4-fluorophenyl)-4,4-dimethyl-2-oxazoline

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Chemical Property of 2-(2-bromo-4-fluorophenyl)-4,4-dimethyl-2-oxazoline

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Technology Process of 2-(2-bromo-4-fluorophenyl)-4,4-dimethyl-2-oxazoline

There total 5 articles about 2-(2-bromo-4-fluorophenyl)-4,4-dimethyl-2-oxazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 71171-94-3
2-(4-Fluorophenyl)-4,4-dimethyl-4,5-dihydro-oxazole

: 1093868-91-7
2-(2-bromo-4-fluorophenyl)-4,4-dimethyl-2-oxazoline

Guidance literature:: 2-(4-Fluorophenyl)-4,4-dimethyl-4,5-dihydro-oxazole; With 2,2,6,6-tetramethylpiperidinylmagnesium chloride; In tetrahydrofuran; at 25 ℃; for 2h; Schlenk technique; Inert atmosphere;

With 1,2-dibromo-1,1,2,2-tetrachloroethane; In tetrahydrofuran; at 25 ℃; for 12h; Schlenk technique; Inert atmosphere;
DOI:10.1002/ejoc.201403255

Reference yield:

: 124-68-5
2-Amino-2-methyl-1-propanol

: 95383-36-1
2-bromo-4-fluorobenzoyl chloride

: 1093868-91-7
2-(2-bromo-4-fluorophenyl)-4,4-dimethyl-2-oxazoline

Guidance literature:: 2-Amino-2-methyl-1-propanol; 2-bromo-4-fluorobenzoyl chloride; In dichloromethane; at 20 ℃; for 4h;

With thionyl chloride; In toluene; at 0 - 20 ℃; for 1.5h;

With sodium hydrogencarbonate; In water; ethyl acetate; toluene;

Reference yield:

: 1006-41-3
2-bromo-4-fluorobenzoic acid

: 1093868-91-7
2-(2-bromo-4-fluorophenyl)-4,4-dimethyl-2-oxazoline

Guidance literature:: Multi-step reaction with 2 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 20 °C

2.1: dichloromethane / 4 h / 20 °C

2.2: 1.5 h / 0 - 20 °C

With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane;