2-bromo-4,6-dichloro-3-(((trans)-4-methylcyclohexyl)methyl)-3H-imidazo[4,5-c]pyridine

Base Information

Chemical Name:2-bromo-4,6-dichloro-3-(((trans)-4-methylcyclohexyl)methyl)-3H-imidazo[4,5-c]pyridine
CAS No.:1616434-25-3
Molecular Formula:C₁₄H₁₆BrCl₂N₃
Molecular Weight:377.111
Hs Code.:

Synonyms:2-bromo-4,6-dichloro-3-(((trans)-4-methylcyclohexyl)methyl)-3H-imidazo[4,5-c]pyridine

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Chemical Property of 2-bromo-4,6-dichloro-3-(((trans)-4-methylcyclohexyl)methyl)-3H-imidazo[4,5-c]pyridine

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Technology Process of 2-bromo-4,6-dichloro-3-(((trans)-4-methylcyclohexyl)methyl)-3H-imidazo[4,5-c]pyridine

There total 15 articles about 2-bromo-4,6-dichloro-3-(((trans)-4-methylcyclohexyl)methyl)-3H-imidazo[4,5-c]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 1616434-24-2
4,6-dichloro-3-(((trans)-4-methylcyclohexyl)methyl)-3H-imidazo[4,5-c]pyridine

: 1616434-25-3
2-bromo-4,6-dichloro-3-(((trans)-4-methylcyclohexyl)methyl)-3H-imidazo[4,5-c]pyridine

Guidance literature:: With N-Bromosuccinimide; In chloroform; for 1h; Reflux;
DOI:10.1021/acs.jmedchem.1c01524

Reference yield:

: 1658500-49-2
2,6-dichloro-N³-((trans-4-methylcyclohexyl)methyl)pyridine-3,4-diamine

: 1616434-25-3
2-bromo-4,6-dichloro-3-(((trans)-4-methylcyclohexyl)methyl)-3H-imidazo[4,5-c]pyridine

Guidance literature:: Multi-step reaction with 2 steps

1: acetic anhydride / 3 h / 90 °C

2: N-Bromosuccinimide / chloroform / 1 h / Reflux

With N-Bromosuccinimide; acetic anhydride; In chloroform;

Reference yield:

: 934-67-8,4331-54-8,13064-83-0
trans-4-methylcyclohexanecarboxylic acid

: 1616434-25-3
2-bromo-4,6-dichloro-3-(((trans)-4-methylcyclohexyl)methyl)-3H-imidazo[4,5-c]pyridine

Guidance literature:: Multi-step reaction with 5 steps

1.1: thionyl chloride / tetrahydrofuran / 2 h / 20 - 50 °C / Inert atmosphere

1.2: 1 h / 0 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 0 °C / Inert atmosphere; Reflux

3.1: chloro[2-(dicyclohexylphosphino)-3 ,6-dimethoxy-2’,4’, 6’-triisopropyl- 1,1’-biphenyl] [2-(2-aminoethyl)phenyl]palladium(II); lithium hexamethyldisilazane / tetrahydrofuran / 20 °C / Inert atmosphere

4.1: acetic anhydride; hydrogenchloride / 1,4-dioxane / 2 h / 90 °C

5.1: N-Bromosuccinimide / chloroform / 1 h / Reflux

With hydrogenchloride; N-Bromosuccinimide; lithium aluminium tetrahydride; thionyl chloride; chloro[2-(dicyclohexylphosphino)-3 ,6-dimethoxy-2’,4’, 6’-triisopropyl- 1,1’-biphenyl] [2-(2-aminoethyl)phenyl]palladium(II); acetic anhydride; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; chloroform;
DOI:10.1021/acs.jmedchem.1c01524