89283-49-8

Basic information

• Product Name: 2-chloro-N-methyl-5-nitropyrimidin-4-amine
• Synonyms: 2-chloro-N-methyl-5-nitropyrimidin-4-amine;AKOS A0602-0634;(2-chloro-5-nitro-pyrimidin-4-yl)-methyl-amine
• CAS NO: 89283-49-8
• Molecular Formula: C₅H₅ClN₄O₂
• Molecular Weight: 188.57
• Mol File: 89283-49-8.mol
• Article Data: 16

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-chloro-N-methyl-5-nitropyrimidin-4-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-N-methyl-5-nitropyrimidin-4-amine(89283-49-8)
• EPA Substance Registry System: 2-chloro-N-methyl-5-nitropyrimidin-4-amine(89283-49-8)

Safety Data

• Hazardous Substances Data: 89283-49-8(Hazardous Substances Data)

Upstream product

• 74-89-5 methylamine 
• 49845-33-2 2,4-Dichloro-5-nitropyrimidine 

Downstream Products

• 330550-94-2 4-(Methylamino)-2-[[4-(morpholin-4-yl)phenyl]amino]-5-nitropyrimidine 
• 13784-17-3 5-amino-4-methylaminopyrimidine 
• 1350544-88-5 8-phenylamino-9-methyl-2-(4-(4-methylpiperazin-1-yl)phenylamino)-9H-purine 
• 1350545-61-7 4-methylamino-2-(4-(4-methylpiperazin-1-yl)phenylamino)-5-aminopyrimidine 
• 1273307-62-2 2-(2-methoxyethyl)-9-methyl-7-({3-[4-(trifluoromethyl)phenyl]azetidin-1-yl}carbonyl)-7,9-dihydro-8H-purine-8-one hydrochloric acid salt 
• 1273388-39-8 2-(3-methoxypropyl)-9-methyl-7-({3-[4-(trifluoromethyl)phenyl]azetidin-1-yl}carbonyl)-7,9-dihydro-8H-purine-8-one 
• 1273315-68-6 2-cyclohexyl-9-methyl-7-{[2-(trimethylsilyl)ethoxy]methyl}-7,9-dihydro-8H-purine-8-one 
• 1273315-70-0 2-cyclohexyl-9-methyl-7,9-dihydro-8H-purine-8-one 
• 1273315-37-9 9-methyl-2-(2-phenylethyl)-7,9-dihydro-8H-purine-8-one 
• 1273315-21-1 9-methyl-2-[(E)-2-phenylethenyl]-7,9-dihydro-8H-purine-8-one 
• 1273304-67-8 2-benzyl-9-methyl-7-(pyrrolidin-1-ylcarbonyl)-7,9-dihydro-8H-purine-8-one 
• 1273302-07-0 2-(2-fluorophenyl)-9-methyl-7-(pyrrolidin-1-ylcarbonyl)-7,9-dihydro-8H-purine-8-one 
• 1273298-36-4 9-methyl-2-[(E)-2-phenylethenyl]-7-(pyrrolidin-1-ylcarbonyl)-7,9-dihydro-8H-purine-8-one 
• 1273315-11-9 2-chloro-9-methyl-7H-purin-8(9H)-one 

Relevant articles and documents

Synthesis and biological evaluation of pyrimidine derivatives as novel human Pin1 inhibitors

Pin1 (Protein interacting with NIMA1) is a cis–trans isomerase and promotes the amide bond rotation of phosphoSer/Thr-Pro motifs in its substrates. Inhibition of Pin1 might be a novel strategy for developing anticancer agents. Herein, a series of pyrimidi

FUSED-BICYCLIC ARYL QUINOLINONE DERIVATIVES AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS

The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula (I) where A, B, U, V, Z, W1, W2, W3, and R1-R6 are described herein.

INHIBITORS OF THE FIBROBLAST GROWTH FACTOR RECEPTOR

Described herein are inhibitors of FGFR, pharmaceutical compositions including such compounds, and methods of using such compounds and compositions to inhibit the activity of tyrosine kinases.