(2-{[4-({[2-(tert-butoxycarbonyl-methyl-amino)-ethyl]-methyl-carbamoyl}-hydroxy-methyl)-phenoxycarbonyl]-methyl-amino}-ethyl)-methyl-carbamic acid 3-hydroxy-3-methyl-5-oxo-hexyl ester

Base Information

• Chemical Name: (2-{[4-({[2-(tert-butoxycarbonyl-methyl-amino)-ethyl]-methyl-carbamoyl}-hydroxy-methyl)-phenoxycarbonyl]-methyl-amino}-ethyl)-methyl-carbamic acid 3-hydroxy-3-methyl-5-oxo-hexyl ester
• CAS No.: 560101-06-6
• Molecular Formula: C₃₀H₄₈N₄O₁₀
• Molecular Weight: 624.732

Synonyms:(2-{[4-({[2-(tert-butoxycarbonyl-methyl-amino)-ethyl]-methyl-carbamoyl}-hydroxy-methyl)-phenoxycarbonyl]-methyl-amino}-ethyl)-methyl-carbamic acid 3-hydroxy-3-methyl-5-oxo-hexyl ester

Chemical Property of (2-{[4-({[2-(tert-butoxycarbonyl-methyl-amino)-ethyl]-methyl-carbamoyl}-hydroxy-methyl)-phenoxycarbonyl]-methyl-amino}-ethyl)-methyl-carbamic acid 3-hydroxy-3-methyl-5-oxo-hexyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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Useful:

Technology Process of (2-{[4-({[2-(tert-butoxycarbonyl-methyl-amino)-ethyl]-methyl-carbamoyl}-hydroxy-methyl)-phenoxycarbonyl]-methyl-amino}-ethyl)-methyl-carbamic acid 3-hydroxy-3-methyl-5-oxo-hexyl ester

There total 3 articles about (2-{[4-({[2-(tert-butoxycarbonyl-methyl-amino)-ethyl]-methyl-carbamoyl}-hydroxy-methyl)-phenoxycarbonyl]-methyl-amino}-ethyl)-methyl-carbamic acid 3-hydroxy-3-methyl-5-oxo-hexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

carbonic acid 4-({[2-(tert-butoxycarbonyl-methyl-amino)-ethyl]-methyl-carbamoyl}-hydroxy-methyl)-phenyl ester 4-nitro-phenyl ester (560101-04-4) + methyl-(2-methylamino-ethyl)-carbamic acid 3-hydroxy-3-methyl-5-oxo-hexyl ester; compound with trifluoro-acetic acid → (2-{[4-({[2-(tert-butoxycarbonyl-methyl-amino)-ethyl]-methyl-carbamoyl}-hydroxy-methyl)-phenoxycarbonyl]-methyl-amino}-ethyl)-methyl-carbamic acid 3-hydroxy-3-methyl-5-oxo-hexyl ester (560101-06-6)

Guidance literature:

With triethylamine;

DOI:10.1002/anie.200390108

Reference yield:

4-hydroxymandelic acid (1198-84-1) → (2-{[4-({[2-(tert-butoxycarbonyl-methyl-amino)-ethyl]-methyl-carbamoyl}-hydroxy-methyl)-phenoxycarbonyl]-methyl-amino}-ethyl)-methyl-carbamic acid 3-hydroxy-3-methyl-5-oxo-hexyl ester (560101-06-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 49 percent / 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide; 1-hydroxybenzotriazole

2: 90 percent / Et₃N

With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine;

DOI:10.1002/anie.200390108

Reference yield:

bis(1,1-dimethylethyl) [1,2-ethylenediamine]-1,1'-dicarboxylate (177587-81-4) → (2-{[4-({[2-(tert-butoxycarbonyl-methyl-amino)-ethyl]-methyl-carbamoyl}-hydroxy-methyl)-phenoxycarbonyl]-methyl-amino}-ethyl)-methyl-carbamic acid 3-hydroxy-3-methyl-5-oxo-hexyl ester (560101-06-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 49 percent / 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide; 1-hydroxybenzotriazole

2: 90 percent / Et₃N

With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine;

DOI:10.1002/anie.200390108

upstream raw materials:

carbonic acid 4-({[2-(tert-butoxycarbonyl-methyl-amino)-ethyl]-methyl-carbamoyl}-hydroxy-methyl)-phenyl ester 4-nitro-phenyl ester

4-hydroxymandelic acid

bis(1,1-dimethylethyl) [1,2-ethylenediamine]-1,1'-dicarboxylate

Downstream raw materials:

carbonic acid {[2-(tert-butoxycarbonyl-methyl-amino)-ethyl]-methyl-carbamoyl}-[4-({2-[(3-hydroxy-3-methyl-5-oxo-hexyloxycarbonyl)-methyl-amino]-ethyl}-methyl-carbamoyloxy)-phenyl]-methyl ester 4-nitro-phenyl ester

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