1-methyl-5-(2-((6-(methylsulfonyl)pyridin-3-yl)oxy)-5-nitrophenyl)pyrrolidin-2-one

Base Information

Chemical Name:1-methyl-5-(2-((6-(methylsulfonyl)pyridin-3-yl)oxy)-5-nitrophenyl)pyrrolidin-2-one
CAS No.:1616280-63-7
Molecular Formula:C₁₇H₁₇N₃O₆S
Molecular Weight:391.404
Hs Code.:

Synonyms:1-methyl-5-(2-((6-(methylsulfonyl)pyridin-3-yl)oxy)-5-nitrophenyl)pyrrolidin-2-one

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Chemical Property of 1-methyl-5-(2-((6-(methylsulfonyl)pyridin-3-yl)oxy)-5-nitrophenyl)pyrrolidin-2-one

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Technology Process of 1-methyl-5-(2-((6-(methylsulfonyl)pyridin-3-yl)oxy)-5-nitrophenyl)pyrrolidin-2-one

There total 8 articles about 1-methyl-5-(2-((6-(methylsulfonyl)pyridin-3-yl)oxy)-5-nitrophenyl)pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1616279-53-8
methyl 4-azido-4-(2-chloro-5-nitrophenyl)butanoate

: 1616280-63-7
1-methyl-5-(2-((6-(methylsulfonyl)pyridin-3-yl)oxy)-5-nitrophenyl)pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: tributylphosphine; water / tetrahydrofuran / 0.5 h / 20 °C

2: triethylamine / methanol / 24 h / 50 °C

3: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide / 0.5 h / 20 °C

4: potassium carbonate / N,N-dimethyl acetamide / 16 h / 120 °C

With tributylphosphine; water; sodium hydride; potassium carbonate; triethylamine; In tetrahydrofuran; methanol; N,N-dimethyl acetamide; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2016.10.085

Reference yield:

: 1314725-24-0
5-(2-chloro-5-nitrophenyl)pyrrolidin-2-one

: 1616280-63-7
1-methyl-5-(2-((6-(methylsulfonyl)pyridin-3-yl)oxy)-5-nitrophenyl)pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide / 0.5 h / 20 °C

2: potassium carbonate / N,N-dimethyl acetamide / 16 h / 120 °C

With sodium hydride; potassium carbonate; In tetrahydrofuran; N,N-dimethyl acetamide; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2016.10.085

Reference yield:

: 6361-21-3
2-chloro-5-nitrobenzaldehyde

: 1616280-63-7
1-methyl-5-(2-((6-(methylsulfonyl)pyridin-3-yl)oxy)-5-nitrophenyl)pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 8 steps

1: zinc(II) iodide / dichloromethane / 24 h / 20 °C

2: trifluoroacetic acid / dichloromethane; water / 48 h / 20 °C

3: 1,8-diazabicyclo[5.4.0]undec-7-ene / 2 h / 20 °C

4: diethylazodicarboxylate; diphenyl phosphoryl azide; triphenylphosphine / tetrahydrofuran / 0 - 20 °C

5: tributylphosphine; water / tetrahydrofuran / 0.5 h / 20 °C

6: triethylamine / methanol / 24 h / 50 °C

7: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide / 0.5 h / 20 °C

8: potassium carbonate / N,N-dimethyl acetamide / 16 h / 120 °C

With tributylphosphine; diphenyl phosphoryl azide; water; sodium hydride; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; triphenylphosphine; trifluoroacetic acid; zinc(II) iodide; diethylazodicarboxylate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide; 1: |Reformatsky Reaction / 4: |Mitsunobu Displacement;
DOI:10.1016/j.bmcl.2016.10.085