1-O-(tert-butyldimethylsilyl)-3-(2'-hydroxy-3',6'-dimethylphenyl)-3,3-dimethylpropanol

Base Information

Chemical Name:1-O-(tert-butyldimethylsilyl)-3-(2'-hydroxy-3',6'-dimethylphenyl)-3,3-dimethylpropanol
CAS No.:261364-41-4
Molecular Formula:C₁₉H₃₄O₂Si
Molecular Weight:322.563
Hs Code.:

Synonyms:1-O-(tert-butyldimethylsilyl)-3-(2'-hydroxy-3',6'-dimethylphenyl)-3,3-dimethylpropanol

Suppliers and Price of 1-O-(tert-butyldimethylsilyl)-3-(2'-hydroxy-3',6'-dimethylphenyl)-3,3-dimethylpropanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-O-(tert-butyldimethylsilyl)-3-(2'-hydroxy-3',6'-dimethylphenyl)-3,3-dimethylpropanol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-O-(tert-butyldimethylsilyl)-3-(2'-hydroxy-3',6'-dimethylphenyl)-3,3-dimethylpropanol

There total 5 articles about 1-O-(tert-butyldimethylsilyl)-3-(2'-hydroxy-3',6'-dimethylphenyl)-3,3-dimethylpropanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 92617-58-8
3-(2'-hydroxy-3',6'-dimethylphenyl)-3,3-dimethylpropanol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 261364-41-4
1-O-(tert-butyldimethylsilyl)-3-(2'-hydroxy-3',6'-dimethylphenyl)-3,3-dimethylpropanol

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 2h;

Reference yield:

: 924-50-5
Methyl 3,3-dimethylacrylate

: 261364-41-4
1-O-(tert-butyldimethylsilyl)-3-(2'-hydroxy-3',6'-dimethylphenyl)-3,3-dimethylpropanol

Guidance literature:: Multi-step reaction with 3 steps

1: 48 percent / MeSO₃H / 24 h / 70 °C

2: 75 percent / LiAlH₄ / tetrahydrofuran / 0 - 20 °C

3: 91 percent / Et₃N / CH₂Cl₂ / 20 °C

With lithium aluminium tetrahydride; methanesulfonic acid; triethylamine; In tetrahydrofuran; dichloromethane; 1: lactonization / 2: Reduction / 3: silylation;
DOI:10.1021/jm990498j

Reference yield:

: 40662-15-5
4,4,5,8-tetramethyl-3,4-dihydro-2H-1-benzopyran-2-one

: 261364-41-4
1-O-(tert-butyldimethylsilyl)-3-(2'-hydroxy-3',6'-dimethylphenyl)-3,3-dimethylpropanol

Guidance literature:: Multi-step reaction with 2 steps

1: 75 percent / LiAlH₄ / tetrahydrofuran / 0 - 20 °C

2: 91 percent / Et₃N / CH₂Cl₂ / 20 °C

With lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; dichloromethane; 1: Reduction / 2: silylation;
DOI:10.1021/jm990498j